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Here, we elucidate the spatiotemporal activation of cerebellar lobules in ASD during emotional processing of happy and angry faces in adolescents with ASD and typically developing (TD) controls. Using magnetoencephalography, we calculated dynamic statistical parametric maps across a period of 500\u2009ms after emotional stimuli onset and determined differences between group activity to happy and angry emotions. Following happy face presentation, adolescents with ASD exhibited only left\u2010hemispheric cerebellar activation in a cluster extending from lobule VI to lobule V (compared to TD controls). Following angry face presentation, adolescents with ASD exhibited only midline cerebellar activation (posterior IX vermis). Our findings indicate an early (125\u2013175\u2009ms) overactivation in cerebellar activity only for happy faces and a later overactivation for both happy (250\u2013450\u2009ms) and angry (250\u2013350\u2009ms) faces in adolescents with ASD. The prioritized hemispheric activity (happy faces) could reflect the promotion of a more flexible and adaptive social behavior, while the latter midline activity (angry faces) may guide conforming behavior.<\/jats:p>","DOI":"10.1002\/hbm.25349","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T03:08:16Z","timestamp":1612580896000},"page":"2099-2114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Atypical spatiotemporal activation of cerebellar lobules during emotional face processing in adolescents with autism"],"prefix":"10.1002","volume":"42","author":[{"given":"Charis","family":"Styliadis","sequence":"first","affiliation":[{"name":"Laboratory of Medical Physics, School of Medicine Aristotle University of Thessaloniki  Thessaloniki 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