{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:14:03Z","timestamp":1790766843920,"version":"4.1.0"},"reference-count":99,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS082453"],"award-info":[{"award-number":["R01 NS082453"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS091602"],"award-info":[{"award-number":["R01 NS091602"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Repetitive head impact (RHI) exposure in collision sports may contribute to adverse neurological outcomes in former players. In contrast to a concussion, or mild traumatic brain injury, \u201csubconcussive\u201d RHIs represent a more frequent and asymptomatic form of exposure. The neural network\u2010level signatures characterizing subconcussive RHIs in youth collision\u2010sport cohorts such as American Football are not known. Here, we used resting\u2010state functional MRI to examine default mode network (DMN) functional connectivity (FC) following a single football season in youth players (\n                    <jats:italic>n<\/jats:italic>\n                    = 50, ages 8\u201314) without concussion. Football players demonstrated reduced FC across widespread DMN regions compared with non\u2010collision sport controls at postseason but not preseason. In a subsample from the original cohort (\n                    <jats:italic>n<\/jats:italic>\n                    = 17), players revealed a negative change in FC between preseason and postseason and a positive and compensatory change in FC during the offseason across the majority of DMN regions. Lastly, significant FC changes, including between preseason and postseason and between in\u2010 and off\u2010season, were specific to players at the upper end of the head impact frequency distribution. These findings represent initial evidence of network\u2010level FC abnormalities following repetitive, non\u2010concussive RHIs in youth football. Furthermore, the number of subconcussive RHIs proved to be a key factor influencing DMN FC.\n                  <\/jats:p>","DOI":"10.1002\/hbm.25384","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T07:05:57Z","timestamp":1616051157000},"page":"2529-2545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mapping default mode connectivity alterations following a single season of subconcussive impact exposure in youth football"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-8765","authenticated-orcid":false,"given":"Jesse C.","family":"DeSimone","sequence":"first","affiliation":[{"name":"Advanced Neuroscience Imaging Research (ANSIR) Laboratory University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Department of Radiology University of Texas Southwestern Medical Center  Dallas Texas 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Medicine  Winston Salem North Carolina USA"},{"name":"Department of Radiology \u2013 Neuroradiology Wake Forest School of Medicine  Winston Salem North Carolina USA"},{"name":"Clinical and Translational Sciences Institute Wake Forest School of Medicine  Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Wake Forest School of Medicine  Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Stitzel","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Wake Forest School of Medicine  Winston Salem North Carolina USA"},{"name":"Virginia Tech \u2013 Wake Forest School of Biomedical Engineering Wake Forest School of Medicine  Winston Salem North Carolina USA"},{"name":"Clinical and Translational Sciences Institute Wake Forest School of Medicine  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