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We hypothesized that a voxelwise analysis of thin\u2010section neuromelanin\u2010sensitive MRI (NM\u2010MRI) may help determine the significantly affected regions of the SNpc in early\u2010stage IPD and localize these areas in each nigrosome on high\u2010spatial\u2010resolution susceptibility map\u2010weighted imaging (SMwI). Ninety\u2010six healthy subjects and 50 early\u2010stage IPD patients underwent both a 0.8\u2009\u00d7\u20090.8\u2009\u00d7\u20090.8\u2009mm<jats:sup>3<\/jats:sup> NM\u2010MRI and a 0.5\u2009\u00d7\u20090.5\u2009\u00d7\u20091.0\u2009mm<jats:sup>3<\/jats:sup> multi\u2010echo gradient\u2010recalled echo imaging for SMwI. Both NM\u2010MRI and SMwI templates were created by using image data from the 96 healthy subjects. Permutation\u2010based nonparametric tests were conducted to investigate spatial differences between the two groups in NM\u2010MRI, and the results were displayed on both NM\u2010MRI and SMwI templates. The posterolateral and anteromedial regions of the SNpc in NM\u2010MRI were significantly different between the two groups, corresponding to the nigrosome 1 and nigrosome 2 regions, respectively, on the SMwI template. There were the areas of significant spatial difference in the hypointense SN on SMwI between early\u2010stage IPD patients and healthy subjects. These areas on SMwI were slightly greater than those on NM\u2010MRI, including the areas showing group difference on NM\u2010MRI. Our voxelwise analysis of NM\u2010MRI suggests that two regions (nigrosome 1 and nigrosome 2) of the SNpc are separately affected in early\u2010stage IPD.<\/jats:p>","DOI":"10.1002\/hbm.25406","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T09:41:29Z","timestamp":1615369289000},"page":"2823-2832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Early\u2010stage Parkinson's disease: Abnormal nigrosome 1 and 2 revealed by a voxelwise analysis of neuromelanin\u2010sensitive <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"42","author":[{"given":"Young Hee","family":"Sung","sequence":"first","affiliation":[{"name":"Department of Neurology, Gil Medical Center Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-3314","authenticated-orcid":false,"given":"Young","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gil Medical Center Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9579-4098","authenticated-orcid":false,"given":"Eung Yeop","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine Samsung Medical Center, Gangnam\u2010gu  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa216"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807983116"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26201"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP7133"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.8.1437"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-171135"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.5.2283"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.033"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24920"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00196"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.08.043"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25975"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185117722812"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.045"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-019-02279-w"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26932"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz120"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.11.015"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185118778871"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25553"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1171-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.04.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14009"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28417"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13573"},{"issue":"8","key":"e_1_2_8_30_1","first-page":"1460","article-title":"Comparative study of MRI biomarkers in the substantia nigra to discriminate idiopathic Parkinson's disease","volume":"39","author":"Pyatigorskaya N.","year":"2018","journal-title":"AJNR. 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