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We hypothesize that \u201chealthy\u201d brain areas at a distance from the epileptic focus may respond to the interference of IEDs by generating inhibitory alpha and beta oscillations. We predict that more prominent alpha\u2010beta oscillations can be found in patients with less impaired neurocognitive profile. We performed a source imaging magnetoencephalography study, including 41 focal epilepsy patients: 21 with frontal lobe epilepsy (FLE) and 20 with mesial temporal lobe epilepsy. We investigated the effect of anterior (i.e., frontal and temporal) IEDs on the oscillatory pattern over posterior head regions. We compared cortical oscillations (5\u201380\u2009Hz) temporally linked to 3,749 IEDs (1,945 frontal and 1,803 temporal) versus an equal number of IED\u2010free segments. We correlated results from IED triggered oscillations to global neurocognitive performance. Only frontal IEDs triggered alpha\u2010beta oscillations over posterior head regions. IEDs with higher amplitude triggered alpha\u2010beta oscillations of higher magnitude. The intensity of posterior head region alpha\u2010beta oscillations significantly correlated with a better neuropsychological profile. Our study demonstrated that cerebral cortex protects itself from IEDs with generation of inhibitory alpha\u2010beta oscillations at distant cortical regions. The association of more prominent oscillations with a better cognitive status suggests that this mechanism might play a role in determining the cognitive resilience in patients with FLE.<\/jats:p>","DOI":"10.1002\/hbm.25422","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T07:46:32Z","timestamp":1621323992000},"page":"3352-3365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["How cerebral cortex protects itself from interictal spikes: The alpha\/beta inhibition mechanism"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-1421","authenticated-orcid":false,"given":"Giovanni","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanguy","family":"Hedrich","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Multimodal Functional Imaging Lab McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Sziklas","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marc","family":"Lina","sequence":"additional","affiliation":[{"name":"Departement de Genie Electrique Ecole de Technologie Superieure  Montreal Quebec Canada"},{"name":"Centre De Recherches En Mathematiques  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Grova","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute McGill University  Montreal Quebec Canada"},{"name":"Department of Biomedical Engineering, Multimodal Functional Imaging Lab McGill University  Montreal Quebec Canada"},{"name":"Centre De Recherches En Mathematiques  Montreal Quebec Canada"},{"name":"Department of Physics and PERFORM Centre Concordia University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.1.293"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.4.435"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2003.11.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002967"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.09.029"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ab8113"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21087"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21806"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.05.029"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.11.001"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.1.118"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12760"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.04.261"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000345969.57574.f5"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00584-2"},{"issue":"6","key":"e_1_2_12_17_1","first-page":"S11","article-title":"Cognitive correlates of interictal discharges","volume":"33","author":"Binnie C. 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