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However, the findings are variable and inconsistent, hindering understanding of underlying neuropathology. We conducted a meta\u2010analysis of whole\u2010brain resting\u2010state functional neuroimaging studies in ET compared to healthy controls (HC), using anisotropic effect\u2010size seed\u2010based d mapping, to identify the most consistent brain activity alterations and their relation to clinical features. After systematic literature search, we included 13 studies reporting 14 comparisons, describing 286 ET patients and 254 HC. Subgroup analyses were conducted considering medication status, head tremor status, and methodological factors. Brain activity in ET is altered not only in the cerebellum and cerebral motor cortex, but also in nonmotor cortical regions including prefrontal cortex and insula. Most of the results remained unchanged in subgroup analyses of patients with head tremor, medication\u2010naive patients, studies with statistical threshold correction, and the large subgroup of studies using functional magnetic resonance imaging. These findings not only show consistent and robust abnormalities in specific brain regions but also provide new information on the biology of patient heterogeneity, and thus help to elucidate the pathophysiology of ET.<\/jats:p>","DOI":"10.1002\/hbm.25425","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T11:00:21Z","timestamp":1616756421000},"page":"3156-3167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Abnormalities of intrinsic brain activity in essential tremor: A meta\u2010analysis of resting\u2010state functional imaging"],"prefix":"10.1002","volume":"42","author":[{"given":"Huan","family":"Lan","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu Sichuan China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu 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