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Autism spectrum disorder (ASD) is a socio\u2010cognitive and neurodevelopmental disorder with high neuroanatomical heterogeneity, but the specific patterns of morphological networks in ASD remain largely unexplored at the individual level. In this study, individual\u2010based morphological networks were constructed by using high\u2010resolution structural MRI data from 40 young children with ASD (age range: 2\u20138\u2009years) and 38 age\u2010, gender\u2010, and handedness\u2010matched typically developing children (TDC). Measurements were recorded as threefold. Results showed that compared with TDC, young children with ASD exhibited lower values of small\u2010worldness (i.e., \u03c3) of individual\u2010level morphological brain networks, increased morphological connectivity in cortico\u2010striatum\u2010thalamic\u2010cortical (CSTC) circuitry, and decreased morphological connectivity in the cortico\u2010cortical network. 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The results also highlight the crucial role of abnormal morphological connectivity patterns in the socio\u2010cognitive deficits of ASD and support the possible use of the aberrant developmental patterns of morphological brain networks in revealing new clinically\u2010relevant biomarkers for ASD.<\/jats:p>","DOI":"10.1002\/hbm.25434","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T08:28:20Z","timestamp":1619944100000},"page":"3282-3294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Individual\u2010based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder"],"prefix":"10.1002","volume":"42","author":[{"given":"Changchun","family":"He","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology University of Electronic 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