{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:22:26Z","timestamp":1791375746276,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2015CB856405"],"award-info":[{"award-number":["2015CB856405"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2021,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A large proportion of patients with obsessive\u2013compulsive disorder (OCD) respond unsatisfactorily to pharmacological and psychological treatments. An alternative novel treatment for these patients is repetitive transcranial magnetic stimulation (rTMS). This study aimed to investigate the underlying neural mechanism of rTMS treatment in OCD patients. A total of 37 patients with OCD were randomized to receive real or sham 1\u2010Hz rTMS (14\u2009days, 30\u2009min\/day) over the right pre\u2010supplementary motor area (preSMA). Resting\u2010state functional magnetic resonance imaging data were collected before and after rTMS treatment. The individualized target was defined by a personalized functional connectivity map of the subthalamic nucleus. After treatment, patients in the real group showed a better improvement in the Yale\u2013Brown Obsessive Compulsive Scale than the sham group (\n                    <jats:italic>F<\/jats:italic>\n                    <jats:sub>1,35<\/jats:sub>\n                    \u00a0=\u20096.0,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.019). To show the neural mechanism involved, we identified an \u201c\n                    <jats:italic>ideal target connectivity<\/jats:italic>\n                    \u201d before treatment. Leave\u2010one\u2010out cross\u2010validation indicated that this connectivity pattern can significantly predict patients' symptom improvements (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u2009.60,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.009). After real treatment, the average connectivity strength of the target network significantly decreased in the real but not in the sham group. This network\u2010level change was cross\u2010validated in three independent datasets. Altogether, these findings suggest that personalized magnetic stimulation on preSMA may alleviate obsessive\u2013compulsive symptoms by decreasing the connectivity strength of the target network.\n                  <\/jats:p>","DOI":"10.1002\/hbm.25468","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T05:18:30Z","timestamp":1622783910000},"page":"3833-3844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Pre\u2010supplementary motor network connectivity and clinical outcome of magnetic stimulation in obsessive\u2013compulsive disorder"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7073-5534","authenticated-orcid":false,"given":"Gong\u2010Jun","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University, The School of Mental Health and Psychological Sciences, Anhui Medical University  Hefei China"},{"name":"Institute of Artificial Intelligence Hefei Comprehensive National Science Center  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health  Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Anhui Mental Health Center  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University, The School of Mental Health and Psychological Sciences, Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health  Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University, The School of Mental Health and Psychological Sciences, Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health  Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengjiao","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University, The School of Mental Health and Psychological Sciences, Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health  Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-0042","authenticated-orcid":false,"given":"Tongjian","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University, The School of Mental Health and Psychological Sciences, Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health  Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University, The School of 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