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Voxel\u2010based meta\u2010analysis within the individual disorders and conjunction analysis were employed to reveal common GMV alterations between SUDs and OCD. Meta\u2010analytic coordinates and signed brain volumetric maps determining directed (reduced\/increased) GMV alterations between the disorder groups and controls served as the primary outcome. The separate meta\u2010analysis demonstrated that SUD and OCD patients exhibited widespread GMV reductions in frontocortical regions including prefrontal, cingulate, and insular. Conjunction analysis revealed that the left inferior frontal gyrus (IFG) consistently exhibited decreased GMV across all disorders. Functional characterization suggests that the IFG represents a core hub in the cognitive control network and exhibits bidirectional (Granger) causal interactions with the striatum. Only OCD showed increased GMV in the dorsal striatum with higher changes being associated with more severe OCD symptomatology. Together the findings demonstrate robustly decreased GMV across the disorders in the left IFG, suggesting a transdiagnostic brain structural marker. The functional characterization as a key hub in the cognitive control network and casual interactions with the striatum suggest that deficits in inhibitory control mechanisms may promote compulsivity and loss of control that characterize both disorders.<\/jats:p>","DOI":"10.1002\/hbm.25471","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T10:39:45Z","timestamp":1623235185000},"page":"3871-3886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Common abnormality of gray matter integrity in substance use disorder and obsessive\u2010compulsive disorder: A comparative voxel\u2010based meta\u2010analysis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-9557","authenticated-orcid":false,"given":"Benjamin","family":"Klugah\u2010Brown","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key 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