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Here we compare multi\u2010parametric mapping (MPM) measures across cortical depths for a 7T 500\u2009\u03bcm whole brain acquisition to (a) layer\u2010specific cell measures from the von Economo histology atlas, (b) layer\u2010specific gene expression, using the Allen Human Brain atlas and (c) white matter connections using high\u2010fidelity diffusion tractography, at a 1.3\u2009mm isotropic voxel resolution, from a 300mT\/m Connectom MRI system. We show that R2*, but not R1, across cortical depths is highly correlated with layer\u2010specific cell number and layer\u2010specific gene expression. R1\u2010 and R2*\u2010weighted connectivity strength of cortico\u2010striatal and intra\u2010hemispheric cortical white matter connections was highly correlated with grey matter R1 and R2* across cortical depths. Limitations of the layer\u2010specific relationships demonstrated are at least in part related to the high cross\u2010correlations of von Economo atlas cell counts and layer\u2010specific gene expression across cortical layers. These findings demonstrate the potential and limitations of combining 7T MPMs, gene expression and white matter connections to provide an anatomically precise framework for tracking neurodegenerative disease.<\/jats:p>","DOI":"10.1002\/hbm.25595","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T03:40:06Z","timestamp":1626493206000},"page":"4996-5009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Relating quantitative\n                    <scp>7T MRI<\/scp>\n                    across cortical depths to cytoarchitectonics, gene expression and connectomics"],"prefix":"10.1002","volume":"42","author":[{"given":"Peter","family":"McColgan","sequence":"first","affiliation":[{"name":"Department of Neurophysics Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"},{"name":"Huntington's Disease Research Centre, Institute of Neurology University College London 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