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Numerous voxel\u2010based morphometry (VBM) and resting\u2010state functional imaging studies have provided strong evidence of abnormal brain structure and intrinsic and functional activities in AN, but with inconsistent conclusions. Herein, a whole\u2010brain meta\u2010analysis was conducted on VBM (660 patients with AN, and 740 controls) and resting\u2010state functional imaging (425 patients with AN, and 461 controls) studies that measured differences in the gray matter volume (GMV) and intrinsic functional activity between patients with AN and healthy controls (HCs). Overall, patients with AN displayed decreased GMV in the bilateral median cingulate cortex (extending to the bilateral anterior and posterior cingulate cortex), and left middle occipital gyrus (extending to the left inferior parietal lobe). In resting\u2010state functional imaging studies, patients with AN displayed decreased resting\u2010state functional activity in the bilateral anterior cingulate cortex and bilateral median cingulate cortex, and increased resting\u2010state functional activity in the right parahippocampal gyrus. This multimodal meta\u2010analysis identified reductions of gray matter and functional activity in the anterior and median cingulate in patients with AN, which contributes to further understanding of the pathophysiology of AN.<\/jats:p>","DOI":"10.1002\/hbm.25602","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T04:06:35Z","timestamp":1627013195000},"page":"5154-5169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Structural and functional brain alterations in anorexia nervosa:A multimodal meta\u2010analysis of neuroimaging studies"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-5821","authenticated-orcid":false,"given":"Ting","family":"Su","sequence":"first","affiliation":[{"name":"Medical Imaging Center First Affiliated Hospital of Jinan University  Guangzhou China"},{"name":"Institute of Molecular and Functional Imaging Jinan 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