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This study aimed to define the specific morphological brain network alterations in PD\u2010M, and explore their potential diagnostic value. Twenty\u2010four PD\u2010M patients, 17 PD\u2010N patients, and 29 healthy controls (HC) underwent a structural MRI scan. Similarity between interregional gray matter volume distributions was used to construct individual morphological brain networks. These were analyzed using graph theory and network\u2010based statistics (NBS), and their relationship to neuropsychological tests was assessed. Support vector machine (SVM) was used to perform individual classification. Globally, compared with HC, PD\u2010M showed increased local efficiency (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) in their morphological networks, while PD\u2010N showed decreased normalized path length (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.008). Locally, similar nodal deficits were found in the rectus and lingual gyrus, and cerebellum of both PD groups relative to HC; additionally in PD\u2010M nodal deficits involved several frontal and parietal regions, correlated with cognitive scores. NBS found that similar connections were involved in the default mode and cerebellar networks of both PD groups (to a greater extent in PD\u2010M), while PD\u2010M, but not PD\u2010N, showed altered connections involving the frontoparietal network. Using connections identified by NBS, SVM allowed discrimination with high accuracy between PD\u2010N and HC (90%), PD\u2010M and HC (85%), and between the two PD groups (65%). These results suggest that default mode and cerebellar disruption characterizes PD, more so in PD\u2010M, whereas frontoparietal disruption has diagnostic potential.<\/jats:p>","DOI":"10.1002\/hbm.25606","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T06:10:10Z","timestamp":1627539010000},"page":"5101-5112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Topologically convergent and divergent morphological gray matter networks in early\u2010stage Parkinson's disease with and without mild cognitive impairment"],"prefix":"10.1002","volume":"42","author":[{"given":"Xueling","family":"Suo","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu Sichuan China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"},{"name":"Functional and 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