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However, the potential interaction within the frontoparietal network during WM processing in MDD remains unclear. This study aimed to examine the role of abnormal functional interactions within frontoparietal network in the neuropathological mechanisms of WM deficits in MDD. A total of 40 MDD patients and 47 demographic matched healthy controls (HCs) were included. Functional magnetic resonance imaging and behavioral data were collected during numeric n\u2010back tasks. The psychophysiological interaction and dynamic causal modelling methods were applied to investigate the connectivity within the frontoparietal network in MDD during n\u2010back tasks. The psychophysiological interaction analysis revealed that MDD patients showed increased functional connectivity between the right inferior parietal lobule (IPL) and the right dorsolateral prefrontal cortex (dlPFC) compared with HCs during the 2\u2010back task. The dynamic causal modelling analysis revealed that MDD patients had significantly increased forward modulation connectivity from the right IPL to the right dlPFC than HCs during the 2\u2010back task. Partial correlation was used to calculate the relationship between connective parameters and psychological variables in the MDD group, which showed that the effective connectivity from right IPL to right dlPFC was correlated negatively with the sensitivity index d\u2019 of WM performances and positively with the depressive severity in MDD group. In conclusion, the abnormal functional and effective connectivity between frontal and parietal regions might contribute to explain the neuropathological mechanism of working memory deficits in major depressive disorder.<\/jats:p>","DOI":"10.1002\/hbm.25611","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T10:06:15Z","timestamp":1627639575000},"page":"5217-5229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Increased functional interaction within frontoparietal network during working memory task in major depressive disorder"],"prefix":"10.1002","volume":"42","author":[{"given":"Wanyi","family":"Cao","sequence":"first","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Medical Psychological Institute Central South University  Changsha Hunan China"},{"name":"National Clinical Research 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