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Here, we integrate the connectome\u2010based lesion\u2010symptom mapping framework with sparse partial least squares regression (sPLS\u2010R) to isolate elements of the connectome associated with speech repetition deficits. By mapping over 2,500 connections of the structural connectome in a cohort of 71 stroke\u2010induced cases of aphasia presenting with varying left\u2010hemisphere lesions and repetition impairment, sPLS\u2010R was trained on 50 subjects to algorithmically identify connectomic features on the basis of their predictive value. The highest ranking features were subsequently used to generate a parsimonious predictive model for speech repetition whose predictions were evaluated on a held\u2010out set of 21 subjects. A set of 10 short\u2010 and long\u2010range parieto\u2010temporal connections were identified, collectively delineating the broader circuitry of the dorsal white matter network of the language system. The strongest contributing feature was a short\u2010range connection in the supramarginal gyrus, approximating the cortical localization of area Spt, with parallel long\u2010range pathways interconnecting posterior nodes in supramarginal and superior temporal cortex with anterior nodes in both ventral and\u2014notably\u2014in dorsal premotor cortex, respectively. The collective disruption of these pathways indexed repetition performance in the held\u2010out set of participants, suggesting that these impairments might be characterized as a parietotemporal disconnection syndrome impacting cortical area Spt and its associated white matter circuits of the frontal lobe as opposed to being purely a disconnection of the arcuate fasciculus.<\/jats:p>","DOI":"10.1002\/hbm.25647","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T14:41:42Z","timestamp":1630507302000},"page":"5689-5702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Isolating the white matter circuitry of the dorsal language stream: <scp>Connectome\u2010Symptom<\/scp> Mapping in stroke induced 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