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Using an MRI\u2010compatible system of boots reproducing gait\u2010like plantar stimulation, we investigated the correlation between age and brain fMRI activation during simulated gait in healthy adults. Sixty\u2010seven right\u2010handed healthy volunteers aged between 20 and 77\u2009years old (49.2\u2009\u00b1\u200918.0\u2009years; 35 women) were recruited. Two paradigms were assessed consecutively: (a) gait\u2010like plantar stimulation and (b) chaotic and not gait\u2010related plantar stimulation. Resulting statistical parametric maps were analyzed with a multiple\u2010factor regression that included age and a threshold determined by Monte\u2010Carlo simulation to fulfill a family\u2010wise error rate correction of <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05. In the first paradigm, there was an age\u2010correlated activation of the right pallidum, thalamus and putamen. The second paradigm showed an age\u2010correlated deactivation of both primary visual areas (V1). The subtraction between results of the first and second paradigms showed age\u2010correlated activation of the right presupplementary motor area (Brodmann Area [BA] 6) and right mid\u2010dorsolateral prefrontal cortex (BA9\u201010). Our results show age\u2010correlated activity in areas that have been associated with the control of gait, highlighting the relevance of this simulation model for functional gait study. The specific progressive activation of top hierarchical control areas in simulated gait and advancing age corroborate a progressive loss of automation in healthy older adults.<\/jats:p>","DOI":"10.1002\/hbm.25691","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T07:43:16Z","timestamp":1636098196000},"page":"833-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Specific age\u2010correlated activation of top hierarchical motor control areas during gait\u2010like plantar stimulation: An fMRI study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9681-7637","authenticated-orcid":false,"given":"Henry","family":"Jeanvoine","sequence":"first","affiliation":[{"name":"Department of Radiology, Angers University Hospital University of Angers  Angers 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