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In contrast, meta\u2010analyses of neuroimaging studies in chronic pain conditions have not revealed convergent evidence for robust alterations during experimental pain induction. Against this background, the present neuroimaging meta\u2010analysis combined three different meta\u2010analytic approaches with stringent study selection criteria for case\u2013control functional magnetic resonance imaging experiments during acute pain processing with a focus on chronic pain disorders. Convergent neurofunctional dysregulations in chronic pain patients were observed in the left anterior insula cortex. Seed\u2010based resting\u2010state functional connectivity based on a large publicly available dataset combined with a meta\u2010analytic task\u2010based approach identified the anterior insular region as a key node of an extended bilateral insula\u2010fronto\u2010cingular network, resembling the salience network. Moreover, the meta\u2010analytic decoding showed that this region presents a high probability to be specifically activated during pain\u2010related processes, although we cannot exclude an involvement in autonomic processes. Together, the present findings indicate that dysregulated left anterior insular activity represents a robust neurofunctional maladaptation and potential treatment target in chronic pain disorders.<\/jats:p>","DOI":"10.1002\/hbm.25702","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T01:42:41Z","timestamp":1635990161000},"page":"998-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Dysregulated anterior insula reactivity as robust functional biomarker for chronic pain\u2014Meta\u2010analytic evidence from neuroimaging studies"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-0459","authenticated-orcid":false,"given":"Stefania","family":"Ferraro","sequence":"first","affiliation":[{"name":"The Clinical Hospital of the Chengdu Brain Science Institute, School of Life Science and Technology, MOE Key Laboratory for Neuroinformation, High\u2010Field Magnetic Resonance Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China  Chengdu China"},{"name":"Neuroradiology Department Fondazione Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Klugah\u2010Brown","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of the Chengdu Brain Science Institute, School of Life Science and Technology, MOE Key Laboratory for Neuroinformation, High\u2010Field Magnetic Resonance Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R","family":"Tench","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurosciences, Clinical Neurology University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5259-6374","authenticated-orcid":false,"given":"Shuxia","family":"Yao","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of the Chengdu Brain Science Institute, School of Life Science and Technology, MOE Key Laboratory for Neuroinformation, High\u2010Field Magnetic Resonance Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nigri","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Fondazione Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Demichelis","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Fondazione Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pinardi","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Fondazione Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Bruzzone","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Fondazione Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-9671","authenticated-orcid":false,"given":"Benjamin","family":"Becker","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of the Chengdu Brain Science Institute, School of Life Science and Technology, MOE Key Laboratory for Neuroinformation, High\u2010Field Magnetic Resonance Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.20.2433"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31781-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.142349"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01306-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31823ae69e"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23342"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20718"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.034"},{"key":"e_1_2_7_11_1","unstructured":"Evans A. 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