{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:16:33Z","timestamp":1787505393349,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["FG02\u201008ER64581"],"award-info":[{"award-number":["FG02\u201008ER64581"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["U24\u2010RR021992"],"award-info":[{"award-number":["U24\u2010RR021992"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH084898\u201001A1"],"award-info":[{"award-number":["R01MH084898\u201001A1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    For over a century, neuroscientists have been working toward parcellating the human cortex into distinct neurobiological regions. Modern technologies offer many parcellation methods for healthy cortices acquired through magnetic resonance imaging. However, these methods are suboptimal for personalized neurosurgical application given that pathology and resection distort the cerebrum. We sought to overcome this problem by developing a novel connectivity\u2010based parcellation approach that can be applied at the single\u2010subject level. Utilizing normative diffusion data, we first developed a machine\u2010learning (ML) classifier to learn the typical structural connectivity patterns of healthy subjects. Specifically, the Glasser HCP atlas was utilized as a prior to calculate the streamline connectivity between each voxel and each parcel of the atlas. Using the resultant feature vector, we determined the parcel identity of each voxel in neurosurgical patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a040) and thereby iteratively adjusted the prior. This approach enabled us to create patient\u2010specific maps independent of brain shape and pathological distortion. The supervised ML classifier re\u2010parcellated an average of 2.65% of cortical voxels across a healthy dataset (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0178) and an average of 5.5% in neurosurgical patients. Our patient dataset consisted of subjects with supratentorial infiltrating gliomas operated on by the senior author who then assessed the validity and practical utility of the re\u2010parcellated diffusion data. We demonstrate a rapid and effective ML parcellation approach to parcellation of the human cortex during anatomical distortion. Our approach overcomes limitations of indiscriminately applying atlas\u2010based registration from healthy subjects by employing a voxel\u2010wise connectivity approach based on individual data.\n                  <\/jats:p>","DOI":"10.1002\/hbm.25728","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T09:07:32Z","timestamp":1637917652000},"page":"1358-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Connectivity\u2010based parcellation of normal and anatomically distorted human cerebral cortex"],"prefix":"10.1002","volume":"43","author":[{"given":"Stephane","family":"Doyen","sequence":"first","affiliation":[{"name":"Omniscient Neurotechnology  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nicholas","sequence":"additional","affiliation":[{"name":"Omniscient Neurotechnology  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anujan","family":"Poologaindran","sequence":"additional","affiliation":[{"name":"Brain Mapping Unit, Department of Psychiatry University of Cambridge  Cambridge UK"},{"name":"The Alan Turing Institute British Library  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2231-5196","authenticated-orcid":false,"given":"Lewis","family":"Crawford","sequence":"additional","affiliation":[{"name":"Omniscient Neurotechnology  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-6679","authenticated-orcid":false,"given":"Isabella M.","family":"Young","sequence":"additional","affiliation":[{"name":"Omniscient Neurotechnology  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5199-4573","authenticated-orcid":false,"given":"Rafeael","family":"Romero\u2010Garcia","sequence":"additional","affiliation":[{"name":"Brain Mapping Unit, Department of Psychiatry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5407-2585","authenticated-orcid":false,"given":"Michael E.","family":"Sughrue","sequence":"additional","affiliation":[{"name":"Omniscient Neurotechnology  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.03.007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.10.138"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00726-z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001181"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0845"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13051116"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opy270"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opy271"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opy269"},{"key":"e_1_2_11_11_1","volume-title":"Brodmann's: Localisation in the cerebral cortex","author":"Brodmann K.","year":"2005"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.5.JNS153006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00716"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1145\/2939672.2939785"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.09.021"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3945"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw157"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00008"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00175"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18933"},{"key":"e_1_2_11_23_1","article-title":"Common disconnections in glioma surgery: An anatomic description","volume":"9","author":"Glenn C.","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117012"},{"key":"e_1_2_11_25_1","first-page":"407","article-title":"Subject\u2010specific structural parcellations based on randomized AB\u2010divergences","volume":"10433","author":"Honnorat N.","year":"2017","journal-title":"Medical Image Computing and Computer\u2010Assisted Intervention"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2019.00446\/BIBTEX"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24750"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1070","article-title":"Functional and anatomical connectivity\u2010based parcellation of human cingulate cortex","volume":"8","author":"Jin F.","year":"2018","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21890"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNINF.2017.00035\/BIBTEX"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1385\/NI:2:2:175"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-00697-x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plrev.2014.03.005"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.5.JNS191281"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.117731"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.8.JNS191667"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.01.085"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opy265"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1971400917697342"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00182"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.037"},{"key":"e_1_2_11_42_1","volume-title":"Die cytoarchitektonik der hirnrinde des erwachsenen menschen","author":"Economo C. F.","year":"1925"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-015-9280-7"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/JN.00338.2011"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.25728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25728","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:32:56Z","timestamp":1693139576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.25728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/hbm.25728"],"URL":"https:\/\/doi.org\/10.1002\/hbm.25728","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,26]]},"assertion":[{"value":"2021-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}