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However, most research on biased emotional perception in depression has only focused on unimodal experimental stimuli, the neural basis of potentially biased emotional processing of multimodal inputs remains unclear. Here, we addressed this issue by implementing an audiovisual emotional task during functional MRI scanning sessions with 37 patients with MDD and 37 gender\u2010, age\u2010 and education\u2010matched healthy controls. Participants were asked to distinguish laughing and crying sounds while being exposed to faces with different emotional valences as background. We combined general linear model and psychophysiological interaction analyses to identify abnormal local functional activity and integrative processes during audiovisual emotional processing in MDD patients. At the local neural level, MDD patients showed increased bias activity in the ventromedial prefrontal cortex (vmPFC) while listening to negative auditory stimuli and concurrently processing visual facial expressions, along with decreased dorsolateral prefrontal cortex (dlPFC) activity in both the positive and negative visual facial conditions. At the network level, MDD exhibited significantly decreased connectivity in areas involved in automatic emotional processes and voluntary control systems during perception of negative stimuli, including the vmPFC, dlPFC, insula, as well as the subcortical regions of posterior cingulate cortex and striatum. These findings support a multimodal emotion dysregulation hypothesis for MDD by demonstrating that negative bias effects may be facilitated by the excessive ventral bottom\u2010up negative emotional influences along with incapability in dorsal prefrontal top\u2010down control system.<\/jats:p>","DOI":"10.1002\/hbm.25735","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T08:00:47Z","timestamp":1639123247000},"page":"1449-1462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Negative bias effects during audiovisual emotional processing in major depression disorder"],"prefix":"10.1002","volume":"43","author":[{"given":"Liyuan","family":"Li","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute, High\u2010Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province School of Life Science and Technology, University of Electronic Science and Technology of China  Chengdu P. 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