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Clinical vestibular syndromes may perturb this network, resulting in deficits across a variety of functional domains. Here, we leverage structural and functional neuroimaging to characterize this extended network in healthy control participants and patients with post\u2010concussive vestibular dysfunction (PCVD). Then, 27 healthy control subjects (15 females) and 18 patients with subacute PCVD (12 female) were selected for participation. Eighty\u2010two regions of interest (network nodes) were identified based on previous publications, group\u2010wise differences in BOLD signal amplitude and connectivity, and multivariate pattern analysis on affective tests. Group\u2010specific \u201ccore\u201d networks, as well as a \u201cconsensus\u201d network comprised of connections common to all participants, were then generated based on probabilistic tractography and functional connectivity between the 82 nodes and subjected to analyses of node centrality and community structure. Whereas the consensus network was comprised of affective, integrative, and vestibular nodes, PCVD participants exhibited diminished integration and centrality among vestibular and affective nodes and increased centrality of visual, supplementary motor, and frontal and cingulate eye field nodes. Clinical outcomes, derived from dynamic posturography, were associated with approximately 62% of all connections but best predicted by amygdalar, prefrontal, and cingulate connectivity. No group\u2010wise differences in diffusion metrics or tractography were noted. These findings indicate that cognitive, affective, and proprioceptive substrates contribute to vestibular processing and performance and highlight the need to consider these domains during clinical diagnosis and treatment planning.<\/jats:p>","DOI":"10.1002\/hbm.25737","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T06:00:47Z","timestamp":1638597647000},"page":"1501-1518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The \u201cvestibular neuromatrix\u201d: A proposed, expanded vestibular network from graph theory in post\u2010concussive vestibular dysfunction"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-5297","authenticated-orcid":false,"given":"Jeremy L.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3110-7914","authenticated-orcid":false,"given":"Anna","family":"Trofimova","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-5835","authenticated-orcid":false,"given":"Vishwadeep","family":"Ahluwalia","sequence":"additional","affiliation":[{"name":"Georgia State University  Atlanta Georgia USA"},{"name":"Center for Advanced Brain Imaging Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4990-6052","authenticated-orcid":false,"given":"Jose J.","family":"Casado Garrido","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-5838","authenticated-orcid":false,"given":"Julia","family":"Hurtado","sequence":"additional","affiliation":[{"name":"Shepherd Center  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-0521","authenticated-orcid":false,"given":"Rachael","family":"Frank","sequence":"additional","affiliation":[{"name":"Shepherd Center  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-9917","authenticated-orcid":false,"given":"April","family":"Hodge","sequence":"additional","affiliation":[{"name":"Shepherd Center  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-1579","authenticated-orcid":false,"given":"Russell K.","family":"Gore","sequence":"additional","affiliation":[{"name":"Wallace H. 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