{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:48:29Z","timestamp":1790804909128,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To address the impact of COVID\u201019 olfactory loss on the brain, we analyzed the neural connectivity of the central olfactory system in recently SARS\u2010CoV\u20102 infected subjects with persisting olfactory impairment (hyposmia). Twenty\u2010seven previously SARS\u2010CoV\u20102 infected subjects (10 males, mean age\u2009\u00b1\u2009\n                    <jats:italic>SD<\/jats:italic>\n                    40.0\u2009\u00b1\u20097.6\u2009years) with clinically confirmed COVID\u201019 related hyposmia, and eighteen healthy, never SARS\u2010CoV\u20102 infected, normosmic subjects (6 males, mean age\u2009\u00b1\u2009\n                    <jats:italic>SD<\/jats:italic>\n                    36.0\u2009\u00b1\u20097.1\u2009years), were recruited in a 3 Tesla MRI study including high angular resolution diffusion and resting\u2010state functional MRI acquisitions. Specialized metrics of structural and functional connectivity were derived from a standard parcellation of olfactory brain areas and a previously validated graph\u2010theoretic model of the human olfactory functional network. These metrics were compared between groups and correlated to a clinical index of olfactory impairment. On the scanning day, all subjects were virus\u2010free and cognitively unimpaired. Compared to control, both structural and functional connectivity metrics were found significantly increased in previously SARS\u2010CoV\u20102 infected subjects. Greater residual olfactory impairment was associated with more segregated processing within regions more functionally connected to the anterior piriform cortex. An increased neural connectivity within the olfactory cortex was associated with a recent SARS\u2010CoV\u20102 infection when the olfactory loss was a residual COVID\u201019 symptom. The functional connectivity of the anterior piriform cortex, the largest cortical recipient of afferent fibers from the olfactory bulb, accounted for the inter\u2010individual variability in the sensory impairment. Albeit preliminary, these findings could feature a characteristic brain connectivity response in the presence of COVID\u201019 related residual hyposmia.\n                  <\/jats:p>","DOI":"10.1002\/hbm.25741","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T04:40:01Z","timestamp":1643258401000},"page":"1548-1560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Olfactory loss and brain connectivity after\n                    <scp>COVID<\/scp>\n                    \u201019"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-9786","authenticated-orcid":false,"given":"Fabrizio","family":"Esposito","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"De Micco","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Caiazzo","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Siciliano","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Gerardo","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana,\u201d University of Salerno  Baronissi (Salerno) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Monari","sequence":"additional","affiliation":[{"name":"Department of Mental and Physical Health and Public Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Coppola","sequence":"additional","affiliation":[{"name":"Department of Mental and Physical Health and Public Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Naples 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