{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:36:55Z","timestamp":1787240215730,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG Exc 257"],"award-info":[{"award-number":["DFG Exc 257"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG\u20101802\u201030165"],"award-info":[{"award-number":["RG\u20101802\u201030165"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The gradual accrual of disability over time in progressive multiple sclerosis is believed to be driven by widespread degeneration. Yet another facet of the problem may reside in the loss of the brain's ability to adapt to the damage incurred as the disease progresses. In this study, we attempted to examine whether changes associated with optic neuritis in the structural and functional visual networks can still be discerned in progressive patients even years after the acute insult. Forty\u2010eight progressive multiple sclerosis patients, 21 with and 27 without prior optic neuritis, underwent structural and functional MRI, including DTI and resting state fMRI. Anatomical and functional visual networks were analyzed using graph theory\u2010based methods. While no functional metrics were significantly different between the two groups, anatomical global efficiency and density were significantly lower in the optic neuritis group, despite no significant difference in lesion load between the groups. We conclude that long\u2010standing distal damage to the optic nerve causes trans\u2010synaptic effects and the early ability of the cortex to adapt may be altered, or possibly nullified. We suggest that this limited ability of the brain to compensate should be considered when attempting to explain the accumulation of disability in progressive multiple sclerosis patients.<\/jats:p>","DOI":"10.1002\/hbm.25744","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T02:40:20Z","timestamp":1640054420000},"page":"1590-1597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anatomical and functional visual network patterns in progressive multiple sclerosis"],"prefix":"10.1002","volume":"43","author":[{"given":"Yael","family":"Backner","sequence":"first","affiliation":[{"name":"The fMRI Unit, Department of Neurology Hadassah Medical Organization  Jerusalem Israel"},{"name":"The Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"Zamir","sequence":"additional","affiliation":[{"name":"The fMRI Unit, Department of Neurology Hadassah Medical Organization  Jerusalem Israel"},{"name":"The Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiota","family":"Petrou","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Neurology Hadassah Medical Organization  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Center Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Experimental and Clinical Research Center Max Delbrueck Center for Molecular Medicine and Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Karussis","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Neurology Hadassah Medical Organization  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-6475","authenticated-orcid":false,"given":"Netta","family":"Levin","sequence":"additional","affiliation":[{"name":"The fMRI Unit, Department of Neurology Hadassah Medical Organization  Jerusalem Israel"},{"name":"The Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"329","article-title":"Mechanism of delayed conduction of fellow eyes in patients with optic neuritis","volume":"11","author":"Alshowaeir D.","year":"2018","journal-title":"International Journal of Ophthalmology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14571"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000687"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3880"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000634"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00455"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu335"},{"key":"e_1_2_9_9_1","article-title":"Remodeling functional connectivity in multiple sclerosis: A challenging therapeutic approach","volume":"11","author":"Bassi M. 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