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Previous research suggests a link between increased cortical excitation and neuroplasticity induced by selective serotonin reuptake inhibitors (SSRIs). Whether there are modulations of EIB following SSRI\u2010administration in the healthy human brain, however, remains unclear. Thus, in a randomized double\u2010blind study, we administered a clinically relevant dose of 20\u2009mg escitalopram for 7\u2009days (time when steady state is achieved) in 59 healthy women (28 escitalopram, 31 placebo) on oral contraceptives. We acquired resting\u2010state electroencephalography data at baseline, after a single dose, and at steady state. We assessed 1\/<jats:italic>f<\/jats:italic> slope of the power spectrum as a marker of EIB, compared individual trajectories of 1\/<jats:italic>f<\/jats:italic> slope changes contrasting single dose and 1\u2010week drug intake, and tested the relationship of escitalopram plasma levels and cortical excitatory and inhibitory balance shifts. Escitalopram\u2010intake was associated with decreased 1\/<jats:italic>f<\/jats:italic> slope, indicating an EIB shift in favor of excitation. Furthermore, 1\/<jats:italic>f<\/jats:italic> slope at baseline and after a single dose of escitalopram was associated with 1\/<jats:italic>f<\/jats:italic> slope at steady state. Higher plasma escitalopram levels at a single dose were associated with better maintenance of these EIB changes throughout the drug administration week. 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