{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:46:05Z","timestamp":1782452765570,"version":"3.54.5"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701670"],"award-info":[{"award-number":["81701670"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671282"],"award-info":[{"award-number":["81671282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["Q19H180029"],"award-info":[{"award-number":["Q19H180029"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2022,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Temporal lobe epilepsy (TLE) is a network disorder with a high incidence of memory impairment. Memory processing ability highly depends on the dynamic coordination between distinct modules within the hippocampal network. Here, we investigate the relationship between memory phenotypes and modular alterations of dynamic functional connectivity (FC) in the hippocampal network in TLE patients. Then, 31 healthy controls and 66 TLE patients with hippocampal sclerosis were recruited. The patients were classified into memory\u2010intact (MI, 35 cases) group and memory\u2010deficit (MD, 31 cases) group, each based on individual's Wechsler Memory Scale\u2010Revised score. The sliding\u2010windows approach and graph theory analysis were used to analyze the hippocampal network based on resting state functional magnetic resonance imaging. Temporal properties and modular metrics were calculated. Two discrete and switchable states were revealed: a high modularized state (State I) and a low modularized state (State II), which corresponded to either anterior or posterior hippocampal network dominated pattern. TLE was prone to drive less State I but more State II, and the tendency was more obvious in TLE\u2010MD. Additionally, TLE\u2010MD showed more widespread alterations of modular properties compared with TLE\u2010MI across two states. Furthermore, the dynamic modularity features had unique superiority in discriminating TLE\u2010MD from TLE\u2010MI. These findings demonstrated that state transitions and modular function of dissociable hippocampal networks were altered in TLE and more importantly, they could reflect different memory phenotypes. The trend revealed potential values of dynamic FC in elucidating the mechanism underlying memory impairments in TLE.<\/jats:p>","DOI":"10.1002\/hbm.25763","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T10:09:40Z","timestamp":1640858980000},"page":"1917-1929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dynamic functional connectivity in modular organization of the hippocampal network marks memory phenotypes in temporal lobe epilepsy"],"prefix":"10.1002","volume":"43","author":[{"given":"Hong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-9369","authenticated-orcid":false,"given":"Peiyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China and Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-9036","authenticated-orcid":false,"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-7558","authenticated-orcid":false,"given":"Minming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Second Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm166"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs352"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00920"},{"key":"e_1_2_11_5_1","first-page":"154","article-title":"The neurobiology of cognitive disorders in temporal lobe epilepsy","volume":"7","author":"Bell B.","year":"2011","journal-title":"Nature Reviews Neuroscience"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg034"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e0f80a"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007447"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20625"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01739.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12606"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.011"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.45591"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.05.012"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.07.003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.031"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2961"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2013.0158"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131209"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.11.021"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01629.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142846"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00797.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501242112"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03052.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy042"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp182"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(13)80004-4"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S135561770707004X"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550160019010"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116397"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.079"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22058"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039731"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16283"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx233"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aar2768"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.09.007"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.02.018"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23430"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIT.1982.1056489"},{"key":"e_1_2_11_42_1","doi-asserted-by":"crossref","unstructured":"Lurie D. Kessler D. Bassett D. Betzel R. Breakspear M. Keilholz S. \u2026Calhoun V.(2019).On the nature of resting fMRI and time\u2010varying functional connectivity.","DOI":"10.31234\/osf.io\/xtzre"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.05.008"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(68)90017-1"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.391164"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.10.014"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01053.x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3338"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006905"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007370"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.04.001"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24839"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp012"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6974-3"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt099"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-122414-033634"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1896849"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04723-6"},{"issue":"6","key":"e_1_2_11_59_1","first-page":"S18","article-title":"Everyday memory failures in people with epilepsy","volume":"33","author":"Thompson P. J.","year":"1992","journal-title":"Epilepsia"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2007.11.012"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705120114"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4281-13.2014"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.02.046"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.02.019"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.047"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.25763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T03:40:46Z","timestamp":1693107646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.25763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,4,15]]}},"alternative-id":["10.1002\/hbm.25763"],"URL":"https:\/\/doi.org\/10.1002\/hbm.25763","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,30]]},"assertion":[{"value":"2021-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}