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The diffusion magnetic resonance imaging (dMRI) tractography is now widely used to describe the trajectory of the OCN. However, the complex cranial structure leads to difficulties in fiber orientation distribution (FOD) modeling, fiber tracking, and region of interest (ROI) selection. Currently, the identification of OCN relies on expert manual operation, resulting in challenges, such as the carries high clinical, time\u2010consuming, and labor costs. Thus, we propose a method that can automatically identify OCN from dMRI tractography. First, we choose the multi\u2010shell multi\u2010tissue constraint spherical deconvolution (MSMT\u2010CSD) FOD estimation model and deterministic tractography to describe the 3D trajectory of the OCN. Then, we rely on the well\u2010established computational pipeline and anatomical expertise to create a data\u2010driven OCN tractography atlas from 40 HCP data. We identify six clusters belonging to the OCN from the atlas, including the structures of three kinds of positional relationships (pass between, pass through, and go around) with the red nuclei and two kinds of positional relationships with medial longitudinal fasciculus. Finally, we apply the proposed OCN atlas to identify the OCN automatically from 40 new HCP subjects and two patients with brainstem cavernous malformation. In terms of spatial overlap and visualization, experiment results show that the automatically and manually identified OCN fibers are consistent. Our proposed OCN atlas provides an effective tool for identifying OCN by avoiding the traditional selection strategy of ROIs.<\/jats:p>","DOI":"10.1002\/hbm.25779","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T08:48:24Z","timestamp":1643446104000},"page":"2164-2180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Automatic oculomotor nerve identification based on <scp>data\u2010driven<\/scp> fiber clustering"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-8116","authenticated-orcid":false,"given":"Jiahao","family":"Huang","sequence":"first","affiliation":[{"name":"Institute of Information Processing and Automation, College of Information Engineering, Zhejiang University of Technology  Hangzhou China"},{"name":"Zhejiang Provincial United Key Laboratory of Embedded Systems  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-9369","authenticated-orcid":false,"given":"Mengjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Second Xiangya Hospital Central South University  Hunan China"},{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-8178","authenticated-orcid":false,"given":"Qingrun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Institute of Information Processing and Automation, College of Information Engineering, Zhejiang University of Technology  Hangzhou China"},{"name":"Zhejiang Provincial United Key Laboratory of Embedded Systems  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Information Processing and Automation, College of Information Engineering, Zhejiang University of Technology  Hangzhou China"},{"name":"Zhejiang Provincial United Key Laboratory of Embedded Systems  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Information Processing and Automation, College of Information Engineering, Zhejiang University of Technology  Hangzhou China"},{"name":"Zhejiang Provincial United Key Laboratory of Embedded Systems  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjing","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Information Processing and Automation, College of Information Engineering, Zhejiang University of Technology  Hangzhou China"},{"name":"Zhejiang Provincial United Key Laboratory of Embedded Systems  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80775-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00554"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2032"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135247"},{"key":"e_1_2_10_6_1","volume-title":"Localization in clinical neurology","author":"Brazis P. 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Current problems in diagnostic radiology","volume":"000","author":"Condos A.","year":"2021","journal-title":"Current Problems in Diagnostic Radiology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.07.020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/1932409"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.JNS142169"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2020.101686"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2004.1262185"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn102"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","unstructured":"Guevara M. Rom\u00e1n C. Houenou J. Duclap D. Poupon C. 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