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Nineteen right\u2010handed healthy subjects (9\u2009M and 10\u2009F, mean age 43.15\u2009\u00b1\u20098.34\u2009years) were evaluated by means of functional magnetic resonance imaging (fMRI), asking them to perform explicit, first\u2010person, mental imagery of <jats:italic>fatigue<\/jats:italic>\u2010related multisensory sensations. Short sentences designed to assess the principal manifestations of <jats:italic>fatigue<\/jats:italic> from the Multidimensional Fatigue Symptom Inventory were presented. Participants were asked to imagine the corresponding sensations (Sensory Imagery, SI). As a control, they had to imagine the visual scenes (Visual Imagery, VI) described in short phrases. The SI task (vs. VI task) differentially activated three areas: (i) the precuneus, which is involved in first\u2010person perspective taking; (ii) the left superior temporal sulcus, which is a multisensory integration area; and (iii) the left inferior frontal gyrus, known to be involved in mental imagery network. The SI fMRI task can be used to measure processing involved in mental imagery of <jats:italic>fatigue<\/jats:italic>\u2010related multisensory sensations.<\/jats:p>","DOI":"10.1002\/hbm.25839","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T13:49:58Z","timestamp":1647956998000},"page":"3143-3152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Multisensory mental imagery of <scp><i>fatigue<\/i><\/scp>: Evidence from an <scp>fMRI<\/scp> study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-2984","authenticated-orcid":false,"given":"Barbara","family":"Tomasino","sequence":"first","affiliation":[{"name":"Scientific Institute IRCCS \u201cEugenio Medea\u201d, Polo FVG  Pasian di Prato (UD) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Del 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