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Early\u2010onset schizophrenia provides an opportunity to explore the neuropathology of SZ early in the disorder and without the confound of antipsychotic mediation. However, it remains unexplored what deficits are shared or differ between adolescent early\u2010onset (EOS) and adult\u2010onset schizophrenia (AOS) patients. Here, based on 529 participants recruited from three independent cohorts, we explored AOS and EOS common and unique co\u2010varying patterns by jointly analyzing three MRI features: fractional amplitude of low\u2010frequency fluctuations (fALFF), gray matter (GM), and functional network connectivity (FNC). Furthermore, a prediction model was built to evaluate whether the common deficits in drug\u2010naive SZ could be replicated in chronic patients. Results demonstrated that (1) both EOS and AOS patients showed decreased fALFF and GM in default mode network, increased fALFF and GM in the sub\u2010cortical network, and aberrant FNC primarily related to middle temporal gyrus; (2) the commonly identified regions in drug\u2010naive SZ correlate with PANSS positive significantly, which can also predict PANSS positive in chronic SZ with longer duration of illness. Collectively, results suggest that multimodal imaging signatures shared by two types of drug\u2010naive SZ are also associated with positive symptom severity in chronic SZ and may be vital for understanding the progressive schizophrenic brain structural and functional deficits.<\/jats:p>","DOI":"10.1002\/hbm.25862","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T07:03:39Z","timestamp":1649315019000},"page":"3486-3497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Multimodal brain deficits shared in <scp>early\u2010onset<\/scp> and <scp>adult\u2010onset<\/scp> schizophrenia predict positive symptoms regardless of illness stage"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4755-8269","authenticated-orcid":false,"given":"Aichen","family":"Feng","sequence":"first","affiliation":[{"name":"Brainnetome Center and National Laboratory of 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