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Part of this risk is mediated through pathways altering brain physiology and structure. There is a lack of longitudinal studies examining associations between SLEs and brain structural changes. High\u2010resolution structural magnetic resonance imaging data of 212 healthy subjects were acquired at baseline and after 2\u2009years. Voxel\u2010based morphometry was used to identify associations between SLEs using the Life Events Questionnaire and grey matter volume (GMV) changes during the 2\u2010year period in an ROI approach. Furthermore, we assessed adverse childhood experiences as a possible moderator of SLEs\u2010GMV change associations. SLEs were negatively associated with GMV changes in the left medial prefrontal cortex. This association was stronger when subjects had experienced adverse childhood experiences. The medial prefrontal cortex has previously been associated with stress\u2010related disorders. 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