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A good is defined by a group of determinants characterizing the conditions in which the commodity is offered, including commodity type, cost, risk, time delay, and ambiguity. Previous studies have found that the OFC represents the binary choice outcome in decision\u2010making tasks involving commodity type, cost, risk, and delay. Real\u2010life decisions are often complex and involve uncertainty, rewards, and penalties; however, whether the OFC represents binary choice outcomes in a complex decision\u2010making situation, for example, Iowa gambling task (IGT), remains unclear. Here, we propose that the OFC represents binary choice outcome, that is, advantageous choice versus disadvantageous choice, in the IGT. We propose two hypotheses: first, the activity pattern in the human OFC represents an advantageous choice; and second, choice induces an OFC\u2010related functional network. Using functional magnetic resonance imaging and advanced machine\u2010learning tools, we found that the OFC represented an advantageous choice in the IGT. The OFC representation of advantageous choice was related to decision\u2010making performance. Choice modulated the functional connectivity between the OFC and the superior medial gyrus. In conclusion, the OFC represents an advantageous choice during the IGT. In the framework of a good\u2010based model, the results extend the role of the OFC to complex decision\u2010making situation when making a binary choice.<\/jats:p>","DOI":"10.1002\/hbm.25887","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:10:48Z","timestamp":1651065048000},"page":"3840-3856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The orbitofrontal cortex represents advantageous choice in the Iowa gambling task"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-096X","authenticated-orcid":false,"given":"Rujing","family":"Zha","sequence":"first","affiliation":[{"name":"Department of Radiology, the First Affiliated Hospital of USTC, Department of Psychology, School of Humanities &amp; Social Science, Division of Life Science and Medicine University of Science &amp; Technology of China  Hefei Anhui 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