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However, an association between changes in the functional networks in brain white matter (BWM) and Parkinson's symptoms remains unclear. With confirming evidence that resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) of BWM signals can effectively describe neuronal activity, this study investigated the interactions among BWM functional networks in PD relative to healthy controls (HC). Sixty\u2010eight patients with PD and sixty\u2010three HC underwent rs\u2010fMRI. Twelve BWM functional networks were identified by K\u2010means clustering algorithm, which were further classified as deep, middle, and superficial layers. Network\u2010level interactions were examined via coefficient Granger causality analysis. Compared with the HC, the patients with PD displayed significantly weaker functional interaction strength within the BWM networks, particularly excitatory influences from the superficial to deep networks. The patients also showed significantly weaker inhibitory influences from the deep to superficial networks. Additionally, the sum of the absolutely positive\/negative regression coefficients of the tri\u2010layered networks in the patients was lower relative to HC (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, corrected for false discovery rate). Moreover, we found the functional interactions involving the deep BWM networks negatively correlated with part III of the Unified Parkinson's Disease Rating Scales and Hamilton Depression Scales. Taken together, we demonstrated attenuated BWM interactions in PD and these abnormalities were associated with clinical motor and nonmotor symptoms. These findings may aid understanding of the neuropathology of PD and its progression throughout the nervous system from the perspective of BWM function.<\/jats:p>","DOI":"10.1002\/hbm.25973","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T13:27:49Z","timestamp":1654694869000},"page":"4567-4579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Attenuated brain white matter functional network interactions in Parkinson's disease"],"prefix":"10.1002","volume":"43","author":[{"given":"Li","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Radiology, Xiangya Hospital Central South University  Changsha People's Republic of China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan 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