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Current research challenges include a lack of cross\u2010modal convergence regarding the underlying neural\u2013behavioral mechanisms of mTBI, which hinders therapeutics and outcome management for this frequently under\u2010treated and vulnerable population. We used multi\u2010modality imaging methods including magnetoencephalography (MEG) and diffusion tensor imaging (DTI) to investigate brain\u2013behavior impairment in mTBI related to working memory. A total of 41 participants were recruited, including 23 patients with a first\u2010time mTBI imaged within 3\u2009months of injury (all male, age\u00a0=\u00a029.9, SD\u00a0=\u00a06.9), and 18 control participants (all male, age\u00a0=\u00a027.3, SD\u00a0=\u00a05.3). Whole\u2010brain statistics revealed spatially concomitant functional\u2013structural disruptions in brain\u2013behavior interactions in working memory in the mTBI group compared with the control group. These disruptions are located in the hippocampal\u2013prefrontal region and, additionally, in the amygdala (measured by MEG neural activation and DTI measures of fractional anisotropy in relation to working memory performance; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, two\u2010way ANCOVA, nonparametric permutations, corrected). Impaired brain\u2013behavior connections found in the hippocampal\u2013prefrontal and amygdala circuits indicate brain dysregulation of memory, which may leave mTBI patients vulnerable to increased environmental demands exerting memory resources, leading to related cognitive and emotional psychopathologies. The findings yield clinical implications and highlight a need for early rehabilitation after mTBI, including attention\u2010 and sensory\u2010based behavioral exercises.<\/jats:p>","DOI":"10.1002\/hbm.26003","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T08:41:01Z","timestamp":1657183261000},"page":"5296-5309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Memory retrieval brain\u2013behavior disconnection in mild traumatic brain injury: A magnetoencephalography and diffusion tensor imaging study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-1989","authenticated-orcid":false,"given":"Yuwen","family":"Hung","sequence":"first","affiliation":[{"name":"Martinos Imaging Center at McGovern Institute for Brain Research, Harvard\u2010MIT  Cambridge Massachusetts USA"},{"name":"Program in Neurosciences &amp; Mental Health Hospital for Sick Children Research Institute  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-0306","authenticated-orcid":false,"given":"Marlee","family":"Vandewouw","sequence":"additional","affiliation":[{"name":"Program in Neurosciences &amp; Mental Health Hospital for Sick Children Research Institute  Toronto Ontario Canada"},{"name":"Institute of Biomedical Engineering University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Emami","sequence":"additional","affiliation":[{"name":"Program in Neurosciences &amp; Mental Health Hospital for Sick Children Research Institute  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonya","family":"Bells","sequence":"additional","affiliation":[{"name":"Program in Neurosciences &amp; Mental Health Hospital for Sick Children Research Institute  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Rudberg","sequence":"additional","affiliation":[{"name":"Health Sciences Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leodante","family":"da Costa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery Sunnybrook Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-1171","authenticated-orcid":false,"given":"Benjamin T.","family":"Dunkley","sequence":"additional","affiliation":[{"name":"Program in Neurosciences &amp; Mental Health Hospital for Sick Children Research Institute  Toronto Ontario Canada"},{"name":"Department of Diagnostic Imaging Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Medical Imaging University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.02.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.183086"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000376"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0336-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-013-9237-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.599"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617713000490"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr161"},{"key":"e_1_2_10_12_1","unstructured":"Centers for Disease Control and Prevention. 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