{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:11Z","timestamp":1786977851105,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Transcranial direct current stimulation (tDCS) has been studied as a therapeutic option to alter maladaptive brain functions associated with chronic substance use. We present a randomized, triple\u2010blind, sham\u2010controlled, clinical trial to determine the neural substrates of tDCS effects on drug craving. Sixty participants with methamphetamine use disorder were assigned to two groups: active tDCS (5\u2009x\u20097\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    , 2\u2009mA, 20\u2009min, anode\/cathode over the F4\/Fp1) and sham stimulation. Neuroimaging data of a methamphetamine cue reactivity task were collected immediately before and after stimulation. There was a significant reduction in self\u2010reported craving after stimulation without any significant effect of time\u2010by\u2010group interaction. Our whole\u2010brain analysis demonstrated that there was a global decrease in brain reactivity to cues following sham but not active tDCS. There were significant time\u2010by\u2010group interactions in five main clusters in middle and inferior frontal gyri, anterior insula, inferior parietal lobule, and precuneus with higher activations after active stimulation. There was a significant effect of stimulation type in the relationship between electrical current at the individual level and changes in task\u2010modulated activation. Brain regions with the highest electric current in the prefrontal cortex showed a significant time\u2010by\u2010group interaction in task\u2010modulated connectivity in the frontoparietal network. In this trial, there was no significant effect of the one session of active\u2010F4\/Fp1 tDCS on drug craving self\u2010report compared to sham stimulation. However, activation and connectivity differences induced by active compared to sham stimulation suggested some potential mechanisms of tDCS to modulate neural response to drug cues.\n                  <\/jats:p>","DOI":"10.1002\/hbm.26007","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T01:08:50Z","timestamp":1659402530000},"page":"5340-5357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Transcranial direct current stimulation to modulate\n                    <scp>fMRI<\/scp>\n                    drug cue reactivity in methamphetamine users: A randomized clinical trial"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6902-8798","authenticated-orcid":false,"given":"Hamed","family":"Ekhtiari","sequence":"first","affiliation":[{"name":"Laureate Institute for Brain Research  Tulsa Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazaleh","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Amirkabir University of Technology  Tehran Iran"},{"name":"Iranian National Center for Addiction Studies Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayus","family":"Kuplicki","sequence":"additional","affiliation":[{"name":"Laureate Institute for Brain Research  Tulsa Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Wen","family":"Yeh","sequence":"additional","affiliation":[{"name":"UMKC School of Medicine University of Missouri\u2010Kansas City School of Medicine  Kansa City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon\u2010Hee","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Medical school University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Paulus","sequence":"additional","affiliation":[{"name":"Laureate Institute for Brain Research  Tulsa Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000449485"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv066"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00688"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.06.019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116598"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3475"},{"issue":"83","key":"e_1_2_9_8_1","first-page":"337","article-title":"Functional magnetic resonance imaging\u2010guided personalization of transcranial magnetic stimulation treatment for depression","volume":"7","author":"Cash R. 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