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The hypothalamus is a key integrative area involved in short\u2010 and long\u2010term energy intake regulation. Hence, we examined the effect of hunger state on the hypothalamus network using functional magnetic resonance imaging. In a multicenter study, participants performed a food cue viewing task either fasted or sated on two separate days. We evaluated hypothalamic functional connectivity (FC) using psychophysiological interactions during high versus low caloric food cue viewing in 107 adults (divided into four groups based on age and body mass index [BMI]; age range 24\u201376\u2009years; BMI range 19.5\u201341.5\u00a0kg\/m<jats:sup>2<\/jats:sup>). In the sated compared to the fasted condition, the hypothalamus showed significantly higher FC with the bilateral caudate, the left insula and parts of the left inferior frontal cortex. Interestingly, we observed a significant interaction between hunger state and BMI group in the dorsolateral prefrontal cortex (DLPFC). Participants with normal weight compared to overweight and obesity showed higher FC between the hypothalamus and DLPFC in the fasted condition. The current study showed that task\u2010based FC of the hypothalamus can be modulated by internal (hunger state) and external cues (i.e., food cues with varying caloric content) with a general enhanced communication in the sated state and obesity\u2010associated differences in hypothalamus to DLPFC communication. This could potentially promote overeating in persons with obesity.<\/jats:p>","DOI":"10.1002\/hbm.26059","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T07:04:36Z","timestamp":1662188676000},"page":"418-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The effect of hunger state on hypothalamic functional connectivity in response to food cues"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-923X","authenticated-orcid":false,"given":"Stephanie","family":"Kullmann","sequence":"first","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Department of Internal Medicine, Division of Diabetology, Endocrinology and Nephrology Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Veit","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Crabtree","sequence":"additional","affiliation":[{"name":"The Rowett Institute University of Aberdeen  Aberdeen Scotland"},{"name":"Division of Biomedical Sciences, Centre for Health Science University of the Highlands and Islands  Inverness UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Buosi","sequence":"additional","affiliation":[{"name":"The Rowett Institute University of Aberdeen  Aberdeen Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odysseas","family":"Androutsos","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics University of Thessaly  Volos Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"The Rowett Institute University of Aberdeen  Aberdeen Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Manios","sequence":"additional","affiliation":[{"name":"Department of Nutrition\u2010Dietetics, School of Health Science and Education Harokopio University  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8859-4661","authenticated-orcid":false,"given":"Hubert","family":"Preissl","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Department of Internal Medicine, Division of Diabetology, Endocrinology and Nephrology Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-9612","authenticated-orcid":false,"given":"Paul A. 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