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Hence, we performed a quantitative whole\u2010brain meta\u2010analysis of relevant resting\u2010state functional imaging studies to identify brain regions consistently involved in migraine. A systematic search of studies that investigated the differences in spontaneous brain activity patterns between migraineurs and healthy controls up to April 2022 was conducted. We then performed a whole\u2010brain voxel\u2010wise meta\u2010analysis using the anisotropic effect size version of seed\u2010based <jats:italic>d<\/jats:italic> mapping software. Complementary analyses including jackknife sensitivity analysis, heterogeneity test, publication bias test, subgroup analysis, and meta\u2010regression analysis were conducted as well. In total, 24 studies that reported 31 datasets were finally eligible for our meta\u2010analysis, including 748 patients and 690 controls. In contrast to healthy controls, migraineurs demonstrated consistent and robust decreased spontaneous brain activity in the angular gyrus, visual cortex, and cerebellum, while increased activity in the caudate, thalamus, pons,\u00a0and prefrontal cortex. Results were robust and highly replicable in the following jackknife sensitivity analysis and subgroup analysis. Meta\u2010regression analyses revealed that a higher visual analog scale score in the patient sample was associated with increased spontaneous brain activity in the left thalamus. These findings provided not only a comprehensive overview of spontaneous brain activity patterns impairments, but also useful insights into the pathophysiology of dysfunction in migraine.<\/jats:p>","DOI":"10.1002\/hbm.26085","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T10:46:15Z","timestamp":1663757175000},"page":"571-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Spontaneous brain activity abnormalities in migraine: A meta\u2010analysis of functional neuroimaging"],"prefix":"10.1002","volume":"44","author":[{"given":"Mengjing","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Radiology and Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of 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