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However, how this brain imbalance underlies distinct BD symptoms remains poorly understood. Here, we used a nested\u2010spectral partition (NSP) method to study the segregation, integration, and balance in resting\u2010state brain functional networks in BD patients and healthy controls (HCs). We first confirmed that there was a high deviation in the brain functional network toward more segregation in BD patients than in HCs and that the limbic system had the largest alteration. Second, we demonstrated a network balance of segregation and integration that corresponded to lower anxiety in BD patients but was not related to other symptoms. Subsequently, based on a machine\u2010learning approach, we identified different system\u2010level mechanisms underlying distinct BD symptoms and found that the features related to the brain network balance could predict BD symptoms better than graph theory analyses. Finally, we studied attention\u2010deficit\/hyperactivity disorder (ADHD) symptoms in BD patients and identified specific patterns that distinctly predicted ADHD and BD scores, as well as their shared common domains. Our findings supported an association of brain imbalance with anxiety symptom in BD patients and provided a potential network signature for diagnosing BD. These results contribute to further understanding the neuropathology of BD and to screening ADHD in BD patients.<\/jats:p>","DOI":"10.1002\/hbm.26087","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T12:45:16Z","timestamp":1664196316000},"page":"599-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Segregation, integration and balance in resting\u2010state brain functional networks associated with bipolar disorder symptoms"],"prefix":"10.1002","volume":"44","author":[{"given":"Zhao","family":"Chang","sequence":"first","affiliation":[{"name":"College of Science Xi'an University of Science and Technology  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Science Xi'an University of Science and Technology  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace Engineering, Xi'an Jiaotong University  Xi'an China"},{"name":"National Demonstration Center for Experimental Mechanics Education Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Mind &amp; Brain Sciences and Cognition and Human Behavior Key Laboratory of Hunan Province Hunan Normal University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-9850","authenticated-orcid":false,"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Science Xi'an University of Science and Technology  Xi'an China"},{"name":"State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace Engineering, Xi'an Jiaotong University  Xi'an China"},{"name":"National Demonstration Center for Experimental Mechanics Education Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2010.518624"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950140032004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520100096046"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707001791"},{"key":"e_1_2_11_7_1","unstructured":"Bilder R. 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