{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:32Z","timestamp":1786977932005,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1073041"],"award-info":[{"award-number":["1073041"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Post\u2010traumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) often co\u2010occur in the context of threat to one's life. These conditions also have an overlapping symptomatology and include symptoms of anxiety, poor concentration and memory problems. A major challenge has been articulating the underlying neurobiology of these overlapping conditions. The primary aim of this study was to compare intrinsic functional connectivity between mTBI (without PTSD) and PTSD (without mTBI). The study included functional MRI data from 176 participants: 42 participants with mTBI, 67 with PTSD and a comparison group of 66 age and sex\u2010matched healthy controls. We used network\u2010based statistical analyses for connectome\u2010wide comparisons of intrinsic functional connectivity between mTBI relative to PTSD and controls. Our results showed no connectivity differences between mTBI and PTSD groups. However, we did find that mTBI had significantly reduced connectivity relative to healthy controls within an extensive network of regions including default mode, executive control, visual and auditory networks. The mTBI group also displayed hyperconnectivity between dorsal and ventral attention networks and perceptual regions. The PTSD group also demonstrated abnormal connectivity within these networks relative to controls. Connectivity alterations were not associated with severity of PTSD or post\u2010concussive symptoms in either clinical group. Taken together, the similar profiles of intrinsic connectivity alterations in these two conditions provide neural evidence that can explain, in part, the overlapping symptomatology between mTBI and PTSD.<\/jats:p>","DOI":"10.1002\/hbm.26101","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T13:38:38Z","timestamp":1665149918000},"page":"813-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A comparison of the functional connectome in mild traumatic brain injury and post\u2010traumatic stress disorder"],"prefix":"10.1002","volume":"44","author":[{"given":"Aleksandra","family":"Klimova","sequence":"first","affiliation":[{"name":"Brain Dynamics Centre, Westmead Institute for Medical Research The University of Sydney  Westmead Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-5274","authenticated-orcid":false,"given":"Isabella A.","family":"Breukelaar","sequence":"additional","affiliation":[{"name":"Brain Dynamics Centre, Westmead Institute for Medical Research The University of Sydney  Westmead Australia"},{"name":"School of Psychology University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-819X","authenticated-orcid":false,"given":"Richard A.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Brain Dynamics Centre, Westmead Institute for Medical Research The University of Sydney  Westmead Australia"},{"name":"School of Psychology University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1339-2221","authenticated-orcid":false,"given":"Mayuresh S.","family":"Korgaonkar","sequence":"additional","affiliation":[{"name":"Brain Dynamics Centre, Westmead Institute for Medical Research The University of Sydney  Westmead Australia"},{"name":"Department of Psychiatry, Faculty of Medicine and Health University of Sydney  Westmead Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0840-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2261"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.10.017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02105408"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1163-11.2011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024465317902"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100321"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2011.13.2\/rbryant"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.23.6.718.1024"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe078235"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370049"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720001129"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.01.010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.090175"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.06.029"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.07.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00280"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.454"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0100-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu239"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715001393"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072972"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2016.03.003"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-289.v2"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22615"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2018.10.004"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0574-2"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.252"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22446"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100308"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.090047"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.15141700"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1355617710000743"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22276"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21151"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.02.005"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.126565"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0022580"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23022"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.12.006"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.032"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.07.006"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41923-6"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4752"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-021-00464-1"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.172"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2018.00038"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00062"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23551"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102319"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.01.015"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn068"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000299"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.15"},{"issue":"20","key":"e_1_2_9_58_1","first-page":"22","article-title":"The Mini\u2010International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan D. V.","year":"1998","journal-title":"The Journal of Clinical Psychiatry"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-016-4841-z"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.024"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.110069"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9157-4"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102190"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.04.012"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00711-6"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2013.823561"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9489-y"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5185"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4526"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.158"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007826"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120748"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.26101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:33:01Z","timestamp":1692318781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.26101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,7]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/hbm.26101"],"URL":"https:\/\/doi.org\/10.1002\/hbm.26101","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,7]]},"assertion":[{"value":"2022-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}