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A recent rodent study revealed a novel circuit from the central amygdala (CeA) to the trigeminal motor nucleus (5M), which controls biting attacks. This circuit has yet to be delineated in humans. Ultra\u2010high diffusion\u2010weighted imaging data from the Human Connectome Project (HCP) allow in vivo delineation of circuits identified in other species\u2014for example, the CeA\u20135M pathway\u2014in humans. We hypothesized that the CeA\u20135M circuit could be resolved in humans at both 7 and 3\u2009T. We performed probabilistic tractography between the CeA and 5M in 30 healthy young adults from the HCP database. As a negative control, we performed tractography between the basolateral amygdala (BLAT) and 5M, as CeA is the only amygdalar nucleus with extensive projections to the brainstem. Connectivity strength was operationalized as the number of streamlines between each region of interest. Connectivity strength between CeA\u20135M and BLAT\u20135M within each hemisphere was compared, and CeA\u20135M circuit had significantly stronger connectivity than the BLAT\u20135M circuit, bilaterally at both 7\u2009T (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and 3\u2009T (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). This study is the first to delineate the CeA\u20135M circuit in humans.<\/jats:p>","DOI":"10.1002\/hbm.26104","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T07:05:34Z","timestamp":1665471934000},"page":"1309-1319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Identification of central amygdala and trigeminal motor nucleus connectivity in humans: An <scp>ultra\u2010high<\/scp> field diffusion <scp>MRI<\/scp> study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-1467","authenticated-orcid":false,"given":"Batu","family":"Kaya","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Centre for Multimodal Sensorimotor and Pain Research University of Toronto  Toronto Ontario Canada"},{"name":"University of Toronto Centre for the Study of Pain  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Geha","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine and Dentistry University of Rochester  Rochester New York USA"},{"name":"The Del Monte Institute of Neuroscience  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Nash Family Department of Neuroscience Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Cioffi","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Centre for Multimodal Sensorimotor and Pain Research University of Toronto  Toronto Ontario Canada"},{"name":"University of Toronto Centre for the Study of Pain  Toronto Ontario Canada"},{"name":"Department of Dentistry Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7324-2540","authenticated-orcid":false,"given":"Massieh","family":"Moayedi","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Centre for Multimodal Sensorimotor and Pain Research University of Toronto  Toronto Ontario Canada"},{"name":"University of Toronto Centre for the Study of Pain  Toronto Ontario Canada"},{"name":"Department of Dentistry Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Clinical &amp; Computational Neuroscience, Krembil Research Institute University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.07.067"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0063-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4180"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_8_8_1","volume-title":"Brainstem navigator","author":"Bianciardi M.","year":"2021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116335"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.01.049"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.056"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118543"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23862"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00026-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.09.008"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.027"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13971"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14188"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3785"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2020.09.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.09.046"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00058.2014"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3928\/0098-9134-19990501-08"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00231163"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12011"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1034"},{"key":"e_1_2_8_31_1","first-page":"1","volume-title":"Handbook of behavioral neuroscience","author":"McDonald A. 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