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We aimed to propose a method based on the use of baseline resting\u2010state functional characteristics (i.e., fractional amplitude of low\u2010frequency fluctuations, fALFF) to predict motor progression in PD patients. Resting\u2010state functional magnetic resonance imaging was performed on 48 newly\u2010diagnosed drug\u2010na\u00efve PD patients and 27 age\u2010 and sex\u2010 matched healthy controls (HCs). Two PD subgroups were defined with different annual increase of Unified PD Rating Scale Part III motor scores. Least absolute shrinkage and selection operator regression analysis was performed to explore the baseline region\u2010functional indicators for PD discrimination as well as the predictors for future motor deficits. Two significant models composed of baseline fALFF values from cerebral subregions were proposed. The classification model that distinguished PD patients from HCs (area under the curve [AUC]\u00a0=\u00a00.897) showed the most significant imaging characteristics in the putamen and precentral gyrus. The other prediction model that evaluated the degree of future deterioration of motor symptoms in PD patients (AUC\u00a0=\u00a00.916) showed the most significant imaging characteristics in the superior occipital gyrus and caudate nucleus. Furthermore, the increased regional function in bilateral caudate nuclei was correlated with the lower annual increase in motor deficits in all PD patients. The caudate nucleus might be the core region responsible for future motor deficits in newly\u2010diagnosed PD patients, which may aid the development of disease progression preventive strategies in clinical practice.<\/jats:p>","DOI":"10.1002\/hbm.26110","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T12:58:56Z","timestamp":1666011536000},"page":"901-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Motor progression marker for newly diagnosed drug\u2010na\u00efve patients with Parkinson's disease: A resting\u2010state functional <scp>MRI<\/scp> study"],"prefix":"10.1002","volume":"44","author":[{"given":"Yanbing","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu Sichuan 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