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Here, we present an initial comparison between perfusion measures obtained using hypoxia\u2010induced deoxyhemoglobin and gadolinium in healthy study participants. We hypothesize that resting cerebral perfusion measures obtained using precise changes of deoxyhemoglobin concentration will generate images comparable to those obtained using a clinical standard, gadolinium. Eight healthy study participants were recruited (6F; age 23\u201360). The study was performed using a 3\u2010Tesla scanner with an eight\u2010channel head coil. The experimental protocol consisted of a high\u2010resolution T1\u2010weighted scan followed by two BOLD sequence scans in which each participant underwent a controlled bolus of transient pulmonary hypoxia, and subsequently received an intravenous bolus of gadolinium. The resting perfusion measures calculated using hypoxia\u2010induced deoxyhemoglobin and gadolinium yielded maps that looked spatially comparable. There was no statistical difference between methods in the average voxel\u2010wise measures of mean transit time, relative cerebral blood flow and relative cerebral blood volume, in the gray matter or white matter within each participant. We conclude that perfusion measures generated with hypoxia\u2010induced deoxyhemoglobin are spatially and quantitatively comparable to those generated from a gadolinium injection in the same healthy participant.<\/jats:p>","DOI":"10.1002\/hbm.26131","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T12:30:33Z","timestamp":1667046633000},"page":"1019-1029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Investigations of hypoxia\u2010induced deoxyhemoglobin as a contrast agent for cerebral perfusion imaging"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2419-751X","authenticated-orcid":false,"given":"Ece Su","family":"Sayin","sequence":"first","affiliation":[{"name":"Department of Physiology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Anaesthesia and Pain Management University Health Network, University of Toronto 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