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The dorsal raphe (DR) and median raphe (MR) nuclei are the main source of 5\u2010HT neurons, however, brain connectivity changes in these two nuclei have not been delineated in PD. Here we used resting\u2010state fMRI (rs\u2010fMRI) to characterize functional connectivity profiles of DR and MR and further examine the associations between dysconnectivity of raphe nuclei and clinical phenotypes of PD. We found that DR and MR commonly hypo\u2010connected with the sensorimotor, temporal, and occipital cortex, limbic system, left thalamus, putamen, and cerebellum in PD. DR had unique decreased connectivity with the bilateral prefrontal and cingulate cortices, while MR had lower connectivity with the pons. Moreover, reduced connectivity of DR correlated with depression, drowsiness, and anxiety, whereas dysconnectivity of MR correlated with depression, cognitive deficits, sleep disturbances, and pain. Our findings highlight the complex roles of raphe nuclei in motor and nonmotor symptoms, providing novel insights into the neurophysiological mechanisms underlying pathogenesis of PD.<\/jats:p>","DOI":"10.1002\/hbm.26139","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T16:55:20Z","timestamp":1667667320000},"page":"1070-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Common and unique dysconnectivity profiles of dorsal and median raphe in Parkinson's disease"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1157-7633","authenticated-orcid":false,"given":"Junling","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital Capital Medical University Beijing 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