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We aimed to identify network connectivity that may alter the negative effect of A\u03b2 on cognition. Following assessment of memory performance, resting\u2010state fMRI, and mean cortical PET\u2010A\u03b2, a total of 364 older adults (286 with clinical dementia rating [CDR\u20100], 59 with CDR\u20100.5 and 19 with CDR\u20101, mean age: 74.0\u2009\u00b1\u20096.4\u2009years) from the OASIS\u20103 sample were included in the analysis. Across all participants, a partial least squares regression showed that lower connectivity between posterior medial default mode and frontoparietal networks, higher within\u2010default mode, and higher visual\u2013motor connectivity predict better episodic memory. These connectivities partially mediate the effect of A\u03b2 on episodic memory. These results suggest that connectivity strength between the precuneus cortex and the superior frontal gyri may alter the negative effect of A\u03b2 on episodic memory. In contrast, education was associated with different functional connectivity patterns. In conclusion, functional characteristics of specific brain networks may help identify amyloid\u2010positive individuals with a higher likelihood of memory decline, with implications for AD clinical trials.<\/jats:p>","DOI":"10.1002\/hbm.26148","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:52:34Z","timestamp":1669297954000},"page":"1147-1157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Connectivity between default mode and frontoparietal networks mediates the association between global amyloid\u2010\u03b2 and episodic memory"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-2095","authenticated-orcid":false,"given":"Peter","family":"Zhukovsky","sequence":"first","affiliation":[{"name":"Centre for Addiction and Mental Health Campbell Family Mental Health Research Institute  Toronto 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