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However, the neurological underpinnings of auditory comprehension remain under debate. Here we used multi\u2010modal neuroimaging analyses on a group of patients with low\u2010grade gliomas to localize cortical regions and white matter tracts responsible for auditory language comprehension. Region\u2010of\u2010interests and voxel\u2010level whole\u2010brain analyses showed that cortical areas in the posterior temporal lobe are crucial for language comprehension. The fiber integrity assessed with diffusion tensor imaging of the arcuate fasciculus and the inferior longitudinal fasciculus was strongly correlated with both auditory comprehension and the grey matter volume of the inferior temporal and middle temporal gyri. Together, our findings provide direct evidence for an integrated network of auditory comprehension whereby the superior temporal gyrus and sulcus, the posterior parts of the middle and inferior temporal gyri serve as auditory comprehension cortex, and the arcuate fasciculus and the inferior longitudinal fasciculus subserve as crucial structural connectivity. These findings provide critical evidence on the neural underpinnings of language comprehension.<\/jats:p>","DOI":"10.1002\/hbm.26161","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T14:48:17Z","timestamp":1671029297000},"page":"1603-1616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The cortical regions and white matter tracts underlying auditory comprehension in patients with primary brain tumor"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6805-8474","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital, Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical 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