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Although the claustrum has been involved in several neurodegenerative diseases, specific changes in connections of the claustrum remain unclear in Alzheimer's disease (AD), and Parkinson's disease (PD). Resting\u2010state fMRI and T1\u2010weighted structural 3D images from healthy elderly (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), AD (<jats:italic>n<\/jats:italic>\u00a0=\u00a016), and PD (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) subjects were analyzed. Seed\u2010based FC analysis was performed using CONN FC toolbox and T1\u2010weighted images were analyzed with the Computational Anatomy Toolbox for voxel\u2010based morphometry analysis. While we observed a decreased FC between the left claustrum and sensorimotor cortex, auditory association cortex, and cortical regions associated with social cognition in PD compared with the healthy control group (HC), no significant difference was found in alterations in the FC of both claustrum comparing the HC and AD groups. In the AD group, high FC of claustrum with regions of sensorimotor cortex and cortical regions related to cognitive control, including cingulate gyrus, supramarginal gyrus, and insular cortex were demonstrated. In addition, the structural results show significantly decreased volume in bilateral claustrum in AD and PD compared with HC. There were no significant differences in the claustrum volumes between PD and AD groups so the FC may offer more precise findings in distinguishing changes for claustrum in AD and PD.<\/jats:p>","DOI":"10.1002\/hbm.26171","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T10:57:44Z","timestamp":1671015464000},"page":"1741-1750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Differentiation of claustrum <scp>resting\u2010state<\/scp> functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease"],"prefix":"10.1002","volume":"44","author":[{"given":"Sevilay","family":"Ayyildiz","sequence":"first","affiliation":[{"name":"Anatomy PhD Program, Graduate School of Health Sciences Kocaeli University  Kocaeli Turkey"},{"name":"Department of Anatomy, School of Medicine Istinye University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-5937","authenticated-orcid":false,"given":"Halil Aziz","family":"Velioglu","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Department of Women's and Children's Health Karolinska Institute  Stockholm Sweden"},{"name":"Functional Imaging and Cognitive\u2010Affective Neuroscience Lab (fINCAN) Health Sciences and Technology Research Institute (SABITA), Regenerative and Restorative Medicine Research Center (REMER), Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behcet","family":"Ayyildiz","sequence":"additional","affiliation":[{"name":"Anatomy PhD Program, Graduate School of Health Sciences Kocaeli University  Kocaeli Turkey"},{"name":"Department of Anatomy, School of Medicine Istinye University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernis","family":"Sutcubasi","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Arts and Sciences Acibadem University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutfu","family":"Hanoglu","sequence":"additional","affiliation":[{"name":"Functional Imaging and Cognitive\u2010Affective Neuroscience Lab (fINCAN) Health Sciences and Technology Research Institute (SABITA), Regenerative and Restorative Medicine Research Center (REMER), Istanbul Medipol University  Istanbul Turkey"},{"name":"Department of Neurology, School of Medicine Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubeyir","family":"Bayraktaroglu","sequence":"additional","affiliation":[{"name":"Functional Imaging and Cognitive\u2010Affective Neuroscience Lab (fINCAN) Health Sciences and Technology Research Institute (SABITA), Regenerative and Restorative Medicine Research Center (REMER), Istanbul Medipol University  Istanbul Turkey"},{"name":"Istanbul Medipol University International School of Medicine, Department of Physiology  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology International School of Medicine, Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Atasever","sequence":"additional","affiliation":[{"name":"Istanbul Medipol University International School of Medicine, Department of Anatomy  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-6173","authenticated-orcid":false,"given":"Burak","family":"Yulug","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Alanya Alaaddin Keykubat University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-9907-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-015-0492-x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.06.068"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn151"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07744.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.08.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1661"},{"key":"e_1_2_10_10_1","volume-title":"Brigham Young Scholars Archive","author":"Davis W. 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