{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:47:55Z","timestamp":1787165275013,"version":"build-2736575974"},"reference-count":78,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020326","name":"Instituto D'Or de Pesquisa e Ensino","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cross\u2010modal plasticity in blind individuals has been reported over the past decades showing that nonvisual information is carried and processed by \u201cvisual\u201d brain structures. However, despite multiple efforts, the structural underpinnings of cross\u2010modal plasticity in congenitally blind individuals remain unclear. We mapped thalamocortical connectivity and assessed the integrity of white matter of 10 congenitally blind individuals and 10 sighted controls. We hypothesized an aberrant thalamocortical pattern of connectivity taking place in the absence of visual stimuli from birth as a potential mechanism of cross\u2010modal plasticity. In addition to the impaired microstructure of visual white matter bundles, we observed structural connectivity changes between the thalamus and occipital and temporal cortices. Specifically, the thalamic territory dedicated to connections with the occipital cortex was smaller and displayed weaker connectivity in congenitally blind individuals, whereas those connecting with the temporal cortex showed greater volume and increased connectivity. The abnormal pattern of thalamocortical connectivity included the lateral and medial geniculate nuclei and the pulvinar nucleus. For the first time in humans, a remapping of structural thalamocortical connections involving both unimodal and multimodal thalamic nuclei has been demonstrated, shedding light on the possible mechanisms of cross\u2010modal plasticity in humans. The present findings may help understand the functional adaptations commonly observed in congenitally blind individuals.<\/jats:p>","DOI":"10.1002\/hbm.26192","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T09:01:46Z","timestamp":1674205306000},"page":"2039-2049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reorganization of thalamocortical connections in congenitally blind humans"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-707X","authenticated-orcid":false,"given":"Theo F.","family":"Marins","sequence":"first","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)  Rio de Janeiro Brazil"},{"name":"Post\u2010Graduation Program in Morphological Sciences (PCM) of the Institute of Biomedical Sciences (ICB) Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Russo","sequence":"additional","affiliation":[{"name":"Institute of Biophysics Carlos Chagas Filho (IBCCF) Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Monteiro","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Moll","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Felix","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Bouzas","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Arcanjo","sequence":"additional","affiliation":[{"name":"Centro de Oftalmologia Especializada  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia D.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Institute of Biophysics Carlos Chagas Filho (IBCCF) Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Tovar\u2010Moll","sequence":"additional","affiliation":[{"name":"D'Or Institute for Research and Education (IDOR)  Rio de Janeiro Brazil"},{"name":"Post\u2010Graduation Program in Morphological Sciences (PCM) of the Institute of Biomedical Sciences (ICB) Federal University of Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164677"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1575-14.2015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2017.12.096"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn848"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.10609"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001276"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(91)90076-U"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22738"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.11.4297"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp279"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902840209"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.3.409"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00129.2002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0984-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.09.041"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08215.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.4.2.117"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/38278"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj162"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013928108"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903280302"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.07.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01275-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122863"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199412000-00072"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.22-13-05749.2002"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00114-9"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030027"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1485-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.09.050"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2018.08.012"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00429"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh105"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.06.055"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(02)00456-X"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2384-10.2010"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.11.020"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1256-15.2015"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000488"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0623-6"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/789539"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.07.048"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13173-7"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.06.053"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.15.8751"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.05.014"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3282f13e66"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2021.102809"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1273-4"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9807512"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6029241"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(03)00121-1"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02147.x"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/22106"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn185"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1068\/p3001"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11602-3.Association"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/380526a0"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)01318-0"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20507"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007228"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/HBM.10062"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2004.07.051"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1669-07.2007"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2449"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.020"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr311"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.08.016"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2020.116876"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2020.116923"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.20-07-02664.2000"},{"key":"e_1_2_10_76_1","volume-title":"World Report on Vision","author":"World Health Organization","year":"2019"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2014.01.060"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03630.x"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.04.012"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.26192","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T23:15:15Z","timestamp":1692400515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.26192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/hbm.26192"],"URL":"https:\/\/doi.org\/10.1002\/hbm.26192","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/449009","asserted-by":"object"}]},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"2022-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}