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However, the motor tasks studied to date are largely overly simplistic. This study describes a new approach: a novel event\u2010based simulated drive made operational via MEG compatible driving simulator hardware, paired with differential beamformer methods to characterize the neural correlates of realistic, complex motor activity. We scanned 23 healthy individuals aged 16\u201323\u2009years (mean age\u00a0=\u00a019.5, SD\u00a0=\u00a02.5; 18 males and 5 females, all right\u2010handed) who completed a custom\u2010built repeated trials driving scenario. MEG data were recorded with a 275\u2010channel CTF, and a volumetric magnetic resonance imaging scan was used for MEG source localization. To validate this paradigm, we hypothesized that pedal\u2010use would elicit expected modulation of primary motor responses beta\u2010event\u2010related desynchronization (B\u2010ERD) and movement\u2010related gamma synchrony (MRGS). To confirm the added utility of this paradigm, we hypothesized that the driving task could also probe frontal cognitive control responses (specifically, frontal midline theta [FMT]). Three of 23 participants were removed due to excess head motion (&gt;1.5\u00a0cm\/trial), confirming feasibility. Nonparametric group analysis revealed significant regions of pedal\u2010use related B\u2010ERD activity (at left precentral foot area, as well as bilateral superior parietal lobe: <jats:italic>p\u2009&lt;<\/jats:italic>\u00a0.01 corrected), MRGS (at medial precentral gyrus: <jats:italic>p\u2009&lt;<\/jats:italic>\u00a0.01 corrected), and FMT band activity sustained around planned braking (at bilateral superior frontal gyrus: <jats:italic>p\u2009&lt;<\/jats:italic>\u00a0.01 corrected). This paradigm overcomes the limits of previous efforts by allowing for characterization of the neural correlates of realistic, complex motor activity in terms of brain regions, frequency bands and their dynamic temporal interplay.<\/jats:p>","DOI":"10.1002\/hbm.26197","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T07:38:38Z","timestamp":1673249918000},"page":"2109-2121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An event\u2010based magnetoencephalography study of simulated driving: Establishing a novel paradigm to probe the dynamic interplay of executive and motor function"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-4272","authenticated-orcid":false,"given":"Elizabeth A.","family":"Walshe","sequence":"first","affiliation":[{"name":"Center for Injury Research and Prevention Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P. L.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Lurie Family Foundations' MEG Imaging Center, Department of Radiology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Radiology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Ward McIntosh","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaura K.","family":"Winston","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Radiology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Perelamn School of Medicine, University of Pennysylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Romer","sequence":"additional","affiliation":[{"name":"Annenberg Public Policy Center University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Gaetz","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Prevention Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Lurie Family Foundations' MEG Imaging Center, Department of Radiology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Radiology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania 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