{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:37:58Z","timestamp":1783114678021,"version":"3.54.6"},"reference-count":93,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T00:00:00Z","timestamp":1673136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002784","name":"Canada Excellence Research Chairs, Government of Canada","doi-asserted-by":"publisher","award":["215063"],"award-info":[{"award-number":["215063"]}],"id":[{"id":"10.13039\/501100002784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007631","name":"Canadian Institute for Advanced Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaesthesia combined with functional neuroimaging provides a powerful approach for understanding the brain mechanisms of consciousness. Although propofol is used ubiquitously in clinical interventions that reversibly suppress consciousness, it shows large inter\u2010individual variability, and the brain bases of this variability remain poorly understood. We asked whether three networks key to conscious cognition\u2014the dorsal attention (DAN), executive control (ECN), and default mode (DMN)\u2014underlie responsiveness variability under anaesthesia. Healthy participants (<jats:italic>N<\/jats:italic>\u00a0=\u200917) were moderately anaesthetized during narrative understanding and resting\u2010state conditions inside the Magnetic Resonance Imaging scanner. A target detection task measured behavioural responsiveness. An independent behavioural study (<jats:italic>N<\/jats:italic>\u00a0=\u200925) qualified the attention demands of narrative understanding. Then, 30% of participants were unaffected in their response times, thus thwarting a key aim of anaesthesia\u2014the suppression of behavioural responsiveness. Individuals with stronger functional connectivity within the DAN and ECN, between them, and to the DMN, and with larger grey matter volume in frontal regions were more resilient to anaesthesia. For the first time, we show that responsiveness variability during propofol anaesthesia relates to inherent differences in brain structure and function of the frontoparietal networks, which can be predicted prior to sedation. Results highlight novel markers for improving awareness monitoring during clinical anaesthesia.<\/jats:p>","DOI":"10.1002\/hbm.26199","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T07:38:42Z","timestamp":1673249922000},"page":"2142-2157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Responsiveness variability during anaesthesia relates to inherent differences in brain structure and function of the frontoparietal networks"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8596-1518","authenticated-orcid":false,"given":"Feng","family":"Deng","sequence":"first","affiliation":[{"name":"Trinity College Institute of Neuroscience, School of Psychology Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Taylor","sequence":"additional","affiliation":[{"name":"Trinity College Institute of Neuroscience, School of Psychology Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian M.","family":"Owen","sequence":"additional","affiliation":[{"name":"Brain and Mind Institute Western University  London Canada"},{"name":"Department of Physiology and Pharmacology and Department of Psychology Western University  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhodri","family":"Cusack","sequence":"additional","affiliation":[{"name":"Trinity College Institute of Neuroscience, School of Psychology Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-3978","authenticated-orcid":false,"given":"Lorina","family":"Naci","sequence":"additional","affiliation":[{"name":"Trinity College Institute of Neuroscience, School of Psychology Trinity College Dublin  Dublin Ireland"},{"name":"Global Brain Health Institute Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)50017-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21079"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00830.2009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2003.09.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2007.02.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.048"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"Bola M. Orlowski P. Plomecka M. &Marchewka A.(2019).EEG signal diversity during propofol sedation: An increase in sedated but responsive a decrease in sedated and unresponsive subjects.bioRxiv 444281.","DOI":"10.1101\/444281"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611404104"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20672"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1417.015"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"155","article-title":"Neural correlates of consciousness during general anesthesia using functional magnetic resonance imaging (fMRI)","volume":"150","author":"Bonhomme V. L. G.","year":"2012","journal-title":"Archives Italiennes de Biologie"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181f697f5"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149048"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004669"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00090"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.11.048"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2012.12.003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat7603"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704320104"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.01.004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/65.1.49"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.06.004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-13-05506.1999"},{"issue":"4","key":"e_1_2_9_28_1","first-page":"507","article-title":"Frequency distribution of the values of the correlation coefficient in samples from an indefinitely large population","volume":"10","author":"Fisher R. A.","year":"1915","journal-title":"Biometrika"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20113"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0306"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071043098"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1992.tb01449.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.07.036"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl075"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00492"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz0087"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.008"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.5.477"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14166-2"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090973"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0393"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200701000-00010"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12658-9"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2014.12.005"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.2\/smarek"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/67.1.41"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev034"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.01.003"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-397025-1.00052-X"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.07.028"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.001"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.036"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.01.006"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1407007111"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5577-12.2013"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31525-z"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.11.059"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1910-19.2019"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e3283304032"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu313"},{"key":"e_1_2_9_64_1","volume-title":"The NAP5 steering panel. NAP5. Accidental awareness during general anesthesia in the United Kingdom and Ireland: Report and findings","author":"Pandit J. J.","year":"2014"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040100"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200603000-00011"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0019"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5920.656"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001479"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)11010-9"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.10.014"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.08.014"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep130"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1138-17.2019"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511526817"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1997.9.5.648"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy167"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.05.004"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2815-14.2014"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800005105"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014224"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312848110"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.08.007"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.07.069"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2010.21488"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57695-3"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23341"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60258-1"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23517"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2003.08.003"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx308"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa071"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.26199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T13:45:48Z","timestamp":1692711948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.26199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,8]]},"references-count":93,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,4,15]]}},"alternative-id":["10.1002\/hbm.26199"],"URL":"https:\/\/doi.org\/10.1002\/hbm.26199","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,8]]},"assertion":[{"value":"2022-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}