{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:12:03Z","timestamp":1790615523618,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR\u20102018\u201012365105"],"award-info":[{"award-number":["GR\u20102018\u201012365105"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Primary progressive aphasias (PPAs) are a group of neurodegenerative diseases mainly characterized by language impairment, and with variably presence of dysexecutive syndrome, behavioural disturbances and parkinsonism. Detailed knowledge of neurotransmitters impairment and its association with clinical features hold the potential to develop new tailored therapeutic approaches. In the present study, we applied JuSpace toolbox, which allowed for cross\u2010modal correlation of magnetic resonance imaging (MRI)\u2010based measures with nuclear imaging derived estimates covering various neurotransmitter systems including dopaminergic, serotonergic, noradrenergic, GABAergic and glutamatergic neurotransmission. We included 103 PPA patients and 80 age\u2010matched healthy controls (HC). We tested if the spatial patterns of grey matter volume (GMV) alterations in PPA patients (relative to HC) are correlated with specific neurotransmitter systems. As compared to HC, voxel\u2010based brain changes in PPA were significantly associated with spatial distribution of serotonin, dopamine, and glutamatergic pathways (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.05, False Discovery Rate corrected\u2010corrected). Disease severity was negatively correlated with the strength of GMV colocalization of D1 receptors (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.035) and serotonin transporter (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.020). Moreover, we observed a significant negative correlation between positive behavioural symptoms, as measured with Frontal Behavioural Inventory, and GMV colocalization of D1 receptors (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.007) and serotonin transporter (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001). This pilot study suggests that JuSpace is a helpful tool to indirectly assess neurotransmitter deficits in neurodegenerative dementias and may provide novel insight into disease mechanisms and associated clinical features.\n                  <\/jats:p>","DOI":"10.1002\/hbm.26206","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T13:34:21Z","timestamp":1673962461000},"page":"2245-2253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["<scp>Unravelling<\/scp>\n                    neurotransmitters impairment in primary progressive aphasias"],"prefix":"10.1002","volume":"44","author":[{"given":"Enrico","family":"Premi","sequence":"first","affiliation":[{"name":"Stroke Unit, Department of Neurological and Vision Sciences ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Dukart","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine, Brain and Behaviour (INM\u20107) Research CentreJ\u00fclich  J\u00fclich Germany"},{"name":"Institute of Systems Neuroscience, Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Libri","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pengo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Gadola","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cotelli","sequence":"additional","affiliation":[{"name":"Neuropsychology Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Manenti","sequence":"additional","affiliation":[{"name":"Neuropsychology Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Binetti","sequence":"additional","affiliation":[{"name":"MAC Memory Clinic and Molecular Markers Laboratory IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gazzina","sequence":"additional","affiliation":[{"name":"Neurophysiology Unit, Department of Neurological and Vision Sciences ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Alberici","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Neurological and Vision Sciences ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Magoni","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurological and Vision Sciences ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-9439","authenticated-orcid":false,"given":"Giacomo","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation University of Ferrara and Center for Translational Neurophysiology of Speech and Communication (CTNSC), Italian Institute of Technology (IIT)  Ferrara Italy"},{"name":"Department of Clinical and Behavioural Neurology Santa Lucia Foundation IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"},{"name":"Neurology Unit, Department of Neurological and Vision Sciences ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9814","authenticated-orcid":false,"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"},{"name":"Neurology Unit, Department of Neurological and Vision Sciences ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.21.3.299"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.11.009"},{"key":"e_1_2_13_4_1","first-page":"1","article-title":"Transcranial stimulation in frontotemporal dementia: A randomized, double\u2010blind, sham\u2010controlled trial","volume":"6","author":"Benussi A.","year":"2020","journal-title":"Alzheimer's Dement (New York, NY)"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004232"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25677"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.04.004"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000399"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131427"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.05.016"},{"key":"e_1_2_13_11_1","article-title":"Longitudinal changes in cognition, Behaviours, and functional abilities in the three Main variants of primary progressive aphasia: A literature review","volume":"11","author":"Sablonni\u00e8re J. L.","year":"2021","journal-title":"Brain Sciences"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22444-0"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25244"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00428"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.23.2.jnp168"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439521"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1996.8.2.135"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181cf468d"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.9.1368"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113034"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.014"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi9086"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.09.007"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8762-6"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12033"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx327"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00248-z"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0330-x"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106500"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160178"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210566"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000247630.29222.34"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000673"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.08.002"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160010"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.26206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:44:48Z","timestamp":1692697488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.26206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,4,15]]}},"alternative-id":["10.1002\/hbm.26206"],"URL":"https:\/\/doi.org\/10.1002\/hbm.26206","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,17]]},"assertion":[{"value":"2022-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}