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However, subsystem mechanisms of DMN underlying WMH\u2010related CI remain unclear. The present study recruited WMH patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0206) with mild CI and normal cognition, as well as healthy controls (HC, <jats:italic>n<\/jats:italic>\u00a0=\u00a0102). Static\/dynamic functional connectivity (FC) of the DMN's three subsystems were calculated using resting\u2010state functional MRI. K\u2010means clustering analyses were performed to extract distinct dynamic connectivity states. Compared with the WMH\u2010NC group, the WMH\u2010MCI group displayed lower static FC within medial temporal lobe (MTL) and core subsystem, between core\u2010MTL subsystem, as well as between core and dorsal medial prefrontal cortex subsystem. All these static alterations were positively associated with information processing speed (IPS). Regarding dynamic FC, the WMH\u2010MCI group exhibited higher dynamic FC within MTL subsystem than the HC and WMH\u2010NC groups. Altered dynamic FC within MTL subsystem mediated the relationship between WMH and memory span (indirect effect: \u22120.2251, 95% confidence interval [\u22120.6295, \u22120.0267]). Additionally, dynamic FCs of DMN subsystems could be clustered into two recurring states. For dynamic FCs within MTL subsystem, WMH\u2010MCI subjects exhibited longer mean dwell time (MDT) and higher reoccurrence fraction (RF) in a sparsely connected state (State 2). Altered MDT and RF in State 2 were negatively associated with IPS. Taken together, these findings indicated static\/dynamic FC of DMN subsystems can provide relevant information on cognitive decline from different aspects, which provides a comprehensive view of subsystem mechanisms of DMN underlying WMH\u2010related CI.<\/jats:p>","DOI":"10.1002\/hbm.26215","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T12:51:38Z","timestamp":1675255898000},"page":"2365-2379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Subsystem mechanisms of default mode network underlying white matter hyperintensity\u2010related cognitive impairment"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-6122","authenticated-orcid":false,"given":"Dan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University  Nanjing 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