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The present study tried to classify them based on their cognitive and emotional performance and explored the neural basis underlying this classification using resting\u2010state fMRI (rs\u2010fMRI). Thirty\u2010nine MMD patients were recruited, assessed mental function and MRI scanned. We adopted hierarchical analysis of their mental performance for new subtypes. Next, a three\u2010step analysis, with each step consisting of 10 random cross validation, was conducted for robust brain regions in classifying the three subtypes of patients in a support vector machine (SVM) model with hypergraph of rs\u2010fMRI. We found three new subtypes including high depression\u2010high anxiety\u2010low cognition (HE\u2010LC, 50%), low depression\u2010low anxiety\u2010high cognition (LE\u2010HC, 14%), and low depression\u2010low anxiety\u2010low cognition (LE\u2010LC, 36%), and no hemorrhagic MMD patients fell into the LE\u2010HC group. The temporal and the bilateral superior frontal cortex, and so forth were included in all 10 randomized SVM modeling. The classification accuracy of the final three\u2010way classification model was 67.5% in average of 10 random cross validation. In addition, the <jats:italic>S<\/jats:italic> value between the frontal cortex and the angular cortex was positively correlated with the anxiety score and backward digit span (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Our results might provide a new perspective for MMD classification concerning patients' mental status, guide timely surgery and suggest angular cortex, and so forth should be protected in surgery for cognitive consideration.<\/jats:p>","DOI":"10.1002\/hbm.26218","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T13:41:32Z","timestamp":1676641292000},"page":"2407-2417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Classify patients with Moyamoya disease according to their cognitive performance might be helpful in clinical and practical with support vector machine based on hypergraph"],"prefix":"10.1002","volume":"44","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui People's Republic of China"},{"name":"Anhui Provincial Stereotactic Neurosurgical Institute  Hefei Anhui People's Republic of China"},{"name":"Anhui Key Laboratory of Brain Function and Brain Disease  Hefei Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9960-6859","authenticated-orcid":false,"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Mental Health and Psychological Sciences Anhui Medical University  Hefei Anhui People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3703-9879","authenticated-orcid":false,"given":"Chengyu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui People's Republic of 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