{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:08:09Z","timestamp":1787616489266,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS094743"],"award-info":[{"award-number":["R01NS094743"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hippocampal dentation (HD) refers to a series of ridges (dentes) seen on the inferior aspect of the hippocampus. The degree of HD varies dramatically across healthy individuals, and hippocampal pathology may result in loss of HD. Existing studies show associations between HD and memory performance in healthy adults as well as temporal lobe epilepsy (TLE) patients. However, until now studies relied on visual assessment of HD as no objective methods to quantify HD have been described. In this work, we describe a method to objectively quantify HD by transforming the characteristic 3D surface morphology of HD into a simplified 2D plot for which area under the curve (AUC) was calculated. This was applied to T1w scans of 59 TLE subjects, each with one epileptic hippocampus and one normal appearing hippocampus. Results showed that AUC significantly correlated with the number of dentes based on visual inspection (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) and correctly sorted a set of hippocampi from least to most prominently dentated. Intra\u2010 and inter\u2010rater reliability was nearly perfect (ICC\u2009\u2265\u20090.99). AUC values were significantly lower in epileptic hippocampi compared to contralateral hippocampi (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.00019), consistent with previously published findings. In the left TLE group, the AUC values from the contralateral hippocampi showed a positive trend (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.07) with verbal memory acquisition scores but was not statistically significant. The proposed approach is the first objective, quantitative measurement of dentation described in the literature. The AUC values numerically capture the complex surface contour information of HD and will enable future study of this interesting morphologic feature.<\/jats:p>","DOI":"10.1002\/hbm.26222","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T13:54:39Z","timestamp":1679925279000},"page":"2967-2980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of an objective method to quantify hippocampal dentation"],"prefix":"10.1002","volume":"44","author":[{"given":"Anandh","family":"Kilpattu Ramaniharan","sequence":"first","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuga","family":"Parpura","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike Weng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Baptist Health Medical Group  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-550X","authenticated-orcid":false,"given":"Lawrence","family":"Ver Hoef","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Birmingham VA Medical Center, Neurology Service  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.104323"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/anatomia1010005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.04.036"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23856"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/10.5.413"},{"key":"e_1_2_10_7_1","unstructured":"Cignoni P. Callieri M. Corsini M. Dellepiane M. Ganovelli F. &Ranzuglia G.(2008).Meshlab: An open\u2010source mesh processing tool.European interdisciplinary cybersecurity conference.https:\/\/doi.org\/10.2312\/LocalChapterEvents\/ItalChap\/ItalianChapConf2008\/129\u2010136"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-016-0541-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.09.032"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17211"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.04.10.487750"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4822961"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","unstructured":"Taubin G.(1995).A signal processing approach to fair surface design.Proceedings of the 22nd annual conference on Computer graphics and interactive techniques.","DOI":"10.1145\/218380.218473"},{"key":"e_1_2_10_16_1","article-title":"Structural variation in hippocampal dentations among healthy young adults","author":"Hove J.","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.546312"},{"key":"e_1_2_10_18_1","article-title":"Quantifying hippocampal dentation in epilepsy: A comparison of absolute mean curvature versus visual inspection and their memory correlates","author":"Ver Hoef L.","year":"2020","journal-title":"ISMRM"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22627"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:43:12Z","timestamp":1692682992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.26222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,27]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/hbm.26222"],"URL":"https:\/\/doi.org\/10.1002\/hbm.26222","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,27]]},"assertion":[{"value":"2022-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}