{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:08:20Z","timestamp":1747148900184,"version":"3.40.5"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012856","name":"Alberta Children's Hospital Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN143304"],"award-info":[{"award-number":["FDN143304"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009003","name":"Hotchkiss Brain Institute, University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Millions of children sustain a concussion annually. Concussion disrupts cellular signaling and neural pathways within the brain but the resulting metabolic disruptions are not well characterized. Magnetic resonance spectroscopy (MRS) can examine key brain metabolites (e.g., <jats:italic>N<\/jats:italic>\u2010acetyl Aspartate (tNAA), glutamate (Glx), creatine (tCr), choline (tCho), and <jats:italic>myo<\/jats:italic>\u2010Inositol (mI)) to better understand these disruptions. In this study, we used MRS to examine differences in brain metabolites between children and adolescents with concussion versus orthopedic injury. Children and adolescents with concussion (<jats:italic>n<\/jats:italic>\u00a0=\u00a0361) or orthopedic injury (OI) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0184) aged 8 to 17\u2009years were recruited from five emergency departments across Canada. MRS data were collected from the left dorsolateral prefrontal cortex (L\u2010DLPFC) using point resolved spectroscopy (PRESS) at 3\u00a0T at a mean of 12\u2009days post\u2010injury (median 10\u2009days post\u2010injury, range 2\u201333\u2009days). Univariate analyses for each metabolite found no statistically significant metabolite differences between groups. Within each analysis, several covariates were statistically significant. Follow\u2010up analyses designed to account for possible confounding factors including age, site, scanner,\u00a0vendor, time since injury, and tissue type (and interactions as appropriate) did not find any metabolite group differences. In the largest sample of pediatric concussion studied with MRS to date, we found no metabolite differences between concussion and OI groups in the L\u2010DLPFC. We suggest that at 2\u2009weeks post\u2010injury in a general pediatric concussion population, brain metabolites in the L\u2010DLPFC are not specifically affected by brain injury.<\/jats:p>","DOI":"10.1002\/hbm.26226","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T18:20:58Z","timestamp":1676053258000},"page":"2493-2508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Brain metabolites measured with magnetic resonance spectroscopy in pediatric concussion and orthopedic injury: An Advancing Concussion Assessment in Pediatrics (A\u2010CAP)\u00a0study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-7346","authenticated-orcid":false,"given":"Parker L.","family":"La","sequence":"first","affiliation":[{"name":"Department of Radiology University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-7999","authenticated-orcid":false,"given":"Julie M.","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9591-706X","authenticated-orcid":false,"given":"Tiffany K.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micaela","family":"Mauthner","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-194X","authenticated-orcid":false,"given":"William","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta and Stollery Children's Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8435-7837","authenticated-orcid":false,"given":"Quynh","family":"Doan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of British Columbia and BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-6361","authenticated-orcid":false,"given":"Miriam H.","family":"Beauchamp","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Montreal and Ste Justine Hospital Research Center  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-2459","authenticated-orcid":false,"given":"Roger","family":"Zemek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Emergency Medicine Children's Hospital of Eastern Ontario, University of Ottawa  Ottawa Ontario Canada"},{"name":"Childrens' Hospital of Eastern Ontario Research Institute University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-2892","authenticated-orcid":false,"given":"Keith Owen","family":"Yeates","sequence":"additional","affiliation":[{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-7075","authenticated-orcid":false,"given":"Ashley D.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"volume-title":"The abbreviated injury scale (AIS)\u20101990 revision","year":"1990","author":"American Association for Automotive Medicine","key":"e_1_2_12_2_1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_3_1","DOI":"10.1016\/s0896-6273(03)00851-1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_4_1","DOI":"10.1007\/s11682-020-00330-6"},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1089\/neu.2013.3213"},{"doi-asserted-by":"publisher","key":"e_1_2_12_6_1","DOI":"10.1016\/j.neuroimage.2022.119330"},{"doi-asserted-by":"publisher","key":"e_1_2_12_7_1","DOI":"10.1097\/PEC.0000000000001360"},{"doi-asserted-by":"publisher","key":"e_1_2_12_8_1","DOI":"10.1007\/978-1-4419-5864-8"},{"doi-asserted-by":"publisher","key":"e_1_2_12_9_1","DOI":"10.1089\/neu.2013.3083"},{"doi-asserted-by":"publisher","key":"e_1_2_12_10_1","DOI":"10.1080\/02699052.2018.1463106"},{"doi-asserted-by":"publisher","key":"e_1_2_12_11_1","DOI":"10.1016\/j.nicl.2020.102258"},{"doi-asserted-by":"publisher","key":"e_1_2_12_12_1","DOI":"10.1097\/PEC.0000000000001252"},{"doi-asserted-by":"publisher","key":"e_1_2_12_13_1","DOI":"10.1097\/RMR.0000000000000063"},{"doi-asserted-by":"publisher","key":"e_1_2_12_14_1","DOI":"10.1002\/cne.23634"},{"doi-asserted-by":"publisher","key":"e_1_2_12_15_1","DOI":"10.1016\/j.neubiorev.2013.09.010"},{"doi-asserted-by":"publisher","key":"e_1_2_12_16_1","DOI":"10.1038\/jid.2014.371"},{"doi-asserted-by":"publisher","key":"e_1_2_12_17_1","DOI":"10.15620\/cdc.5571"},{"doi-asserted-by":"publisher","key":"e_1_2_12_18_1","DOI":"10.1080\/21622965.2016.1229406"},{"doi-asserted-by":"publisher","key":"e_1_2_12_19_1","DOI":"10.1089\/neu.2013.3079"},{"doi-asserted-by":"publisher","key":"e_1_2_12_20_1","DOI":"10.1002\/nbm.3914"},{"doi-asserted-by":"publisher","key":"e_1_2_12_21_1","DOI":"10.1002\/mrm.20901"},{"doi-asserted-by":"publisher","key":"e_1_2_12_22_1","DOI":"10.1089\/neu.2009.0896"},{"doi-asserted-by":"publisher","key":"e_1_2_12_23_1","DOI":"10.1227\/NEU.0000000000000505"},{"doi-asserted-by":"publisher","key":"e_1_2_12_24_1","DOI":"10.1002\/nbm.3575"},{"key":"e_1_2_12_25_1","first-page":"730","article-title":"Volumetric proton spectroscopic imaging of mild traumatic brain injury","volume":"25","author":"Govindaraju V.","year":"2004","journal-title":"American Journal of Neuroradiology"},{"doi-asserted-by":"publisher","key":"e_1_2_12_26_1","DOI":"10.1002\/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V"},{"volume":"42","author":"Harris, A. D., Puts, N. A. J., & Edden, R. A. E.","journal-title":"J. Magn. Reson. Imaging","key":"e_1_2_12_27_1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_28_1","DOI":"10.1186\/1471-2377-11-105"},{"doi-asserted-by":"publisher","key":"e_1_2_12_29_1","DOI":"10.1089\/neu.2009.0962"},{"doi-asserted-by":"publisher","key":"e_1_2_12_30_1","DOI":"10.3389\/fnhum.2021.645209"},{"doi-asserted-by":"publisher","key":"e_1_2_12_31_1","DOI":"10.1002\/mrm.1910320504"},{"doi-asserted-by":"publisher","key":"e_1_2_12_32_1","DOI":"10.1371\/journal.pone.0180973"},{"doi-asserted-by":"publisher","key":"e_1_2_12_33_1","DOI":"10.1016\/j.pmr.2016.01.002"},{"doi-asserted-by":"publisher","key":"e_1_2_12_34_1","DOI":"10.1016\/j.neulet.2011.11.013"},{"doi-asserted-by":"publisher","key":"e_1_2_12_35_1","DOI":"10.1089\/neu.2022.0125"},{"doi-asserted-by":"publisher","key":"e_1_2_12_36_1","DOI":"10.1212\/WNL.0000000000000105"},{"doi-asserted-by":"publisher","key":"e_1_2_12_37_1","DOI":"10.1007\/s00415-012-6626-z"},{"key":"e_1_2_12_38_1","first-page":"265","article-title":"Brain plasticity and behaviour in the developing brain","volume":"20","author":"Kolb B.","year":"2011","journal-title":"Journal of Canadian Academy of Child and Adolescent Psychiatry"},{"doi-asserted-by":"publisher","key":"e_1_2_12_39_1","DOI":"10.1002\/mrm.1910300405"},{"doi-asserted-by":"publisher","key":"e_1_2_12_40_1","DOI":"10.1007\/s11682-012-9181-4"},{"doi-asserted-by":"publisher","key":"e_1_2_12_41_1","DOI":"10.1097\/HTR.0000000000000535"},{"doi-asserted-by":"publisher","key":"e_1_2_12_42_1","DOI":"10.1212\/WNL.0000000000004669"},{"doi-asserted-by":"publisher","key":"e_1_2_12_43_1","DOI":"10.1542\/peds.2011-2083"},{"doi-asserted-by":"publisher","key":"e_1_2_12_44_1","DOI":"10.1002\/mrm.28332"},{"doi-asserted-by":"publisher","key":"e_1_2_12_45_1","DOI":"10.3389\/fneur.2019.00556"},{"doi-asserted-by":"publisher","key":"e_1_2_12_46_1","DOI":"10.3389\/fnene.2013.00011"},{"doi-asserted-by":"publisher","key":"e_1_2_12_47_1","DOI":"10.1002\/nbm.4257"},{"doi-asserted-by":"publisher","key":"e_1_2_12_48_1","DOI":"10.1002\/mrm.21287"},{"doi-asserted-by":"publisher","key":"e_1_2_12_49_1","DOI":"10.1002\/mrm.1910390110"},{"doi-asserted-by":"publisher","key":"e_1_2_12_50_1","DOI":"10.1148\/radiol.2020191037"},{"doi-asserted-by":"publisher","key":"e_1_2_12_51_1","DOI":"10.1002\/nbm.698"},{"doi-asserted-by":"publisher","key":"e_1_2_12_52_1","DOI":"10.1007\/s11064-013-1199-5"},{"doi-asserted-by":"publisher","key":"e_1_2_12_53_1","DOI":"10.1111\/j.1526-4610.2009.01494.x"},{"doi-asserted-by":"publisher","key":"e_1_2_12_54_1","DOI":"10.1002\/hbm.23919"},{"doi-asserted-by":"publisher","key":"e_1_2_12_55_1","DOI":"10.3171\/2010.9.FOCUS10183"},{"doi-asserted-by":"publisher","key":"e_1_2_12_56_1","DOI":"10.1002\/mrm.26091"},{"doi-asserted-by":"publisher","key":"e_1_2_12_57_1","DOI":"10.3109\/02699052.2013.865270"},{"doi-asserted-by":"publisher","key":"e_1_2_12_58_1","DOI":"10.1093\/brain\/awq200"},{"doi-asserted-by":"publisher","key":"e_1_2_12_59_1","DOI":"10.1097\/HTR.0b013e3182795045"},{"doi-asserted-by":"publisher","key":"e_1_2_12_60_1","DOI":"10.1227\/01.NEU.0000316421.58568.AD"},{"doi-asserted-by":"publisher","key":"e_1_2_12_61_1","DOI":"10.1016\/j.acra.2018.01.005"},{"doi-asserted-by":"publisher","key":"e_1_2_12_62_1","DOI":"10.1002\/mrm.1910390107"},{"doi-asserted-by":"publisher","key":"e_1_2_12_63_1","DOI":"10.1002\/hbm.25705"},{"doi-asserted-by":"publisher","key":"e_1_2_12_64_1","DOI":"10.1136\/bmjopen-2017-017012"},{"doi-asserted-by":"publisher","key":"e_1_2_12_65_1","DOI":"10.1089\/neu.2010.1578"},{"doi-asserted-by":"publisher","key":"e_1_2_12_66_1","DOI":"10.1016\/j.jneumeth.2014.09.021"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.26226","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.26226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T13:43:06Z","timestamp":1692711786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.26226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,4,15]]}},"alternative-id":["10.1002\/hbm.26226"],"URL":"https:\/\/doi.org\/10.1002\/hbm.26226","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"type":"print","value":"1065-9471"},{"type":"electronic","value":"1097-0193"}],"subject":[],"published":{"date-parts":[[2023,2,10]]},"assertion":[{"value":"2022-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}