{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:14:51Z","timestamp":1789668891675,"version":"4.0.1"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071531"],"award-info":[{"award-number":["82071531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2023,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, the effects of antidepressants on large\u2010scale brain networks and the neural basis of individual differences in response were explored. A total of 41 patients with major depressive disorder (MDD) and 42 matched healthy controls (HCs) were scanned by resting\u2010state functional magnetic resonance imaging separately at baseline and after a 12\u2010week follow\u2010up. The patients with MDD received escitalopram for 12\u2009weeks. After treatment, patients were classified into those with MDD in remission [MDDr, endpoint 17\u2010item Hamilton Depression Rating Scale (HAMD) total score\u2009\u22647] and those in nonremission (MDDnr). The human Brainnetome Atlas was used to define large\u2010scale networks and compute within\u2010 and between\u2010network resting\u2010state functional connectivity (rsFC). Results showed the decreased subcortical network (SCN)\u2013ventral attention network (VAN) connectivity at baseline increased in patients with MDD after 12\u2010week treatment, and it was comparable with that of HCs. This change was only observed in patients with MDDr. However, the decreased within\u2010network rsFC in SCN and default mode network (DMN) persisted in all patients with MDD, including those with MDDr and MDDnr, after treatment. The strength of SCN\u2013VAN connectivity at baseline was significantly negatively correlated with the reduction rate of HAMD score in all patients with MDD. Thus, SCN\u2013VAN connectivity may be an antidepressant target associated with depressive state changes and a predictor of treatment response to serotonin reuptake inhibitors. The within\u2010network rsFC in SCN and DMN may reflect a trait\u2010like abnormality in MDD. These findings provide further insights into the mechanism of antidepressants and their individual differences in response. The trial name is \u201cAppropriate technology study of MDD diagnosis and treatment based on objective indicators and measurement\u201d (URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\/showproj.aspx?proj=21377\">http:\/\/www.chictr.org.cn\/showproj.aspx?proj=21377<\/jats:ext-link>; registration number: ChiCTR\u2010OOC\u201017012566).<\/jats:p>","DOI":"10.1002\/hbm.26231","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T16:39:12Z","timestamp":1676133552000},"page":"2572-2584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of 12\u2010week escitalopram treatment on resting\u2010state functional connectivity of large\u2010scale brain networks in major depressive disorder"],"prefix":"10.1002","volume":"44","author":[{"given":"Shudong","family":"Zhang","sequence":"first","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital &amp; the Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhou","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital &amp; the Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cui","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital &amp; the Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"},{"name":"Department of Psychiatry Shandong Daizhuang Hospital  Jining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital &amp; the Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital &amp; the Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Feng","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital &amp; the Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Feng","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital &amp; the Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital &amp; the Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongying","family":"Chen","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital &amp; the Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Wu","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; 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